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Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area

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BioMarin Pharmaceutical

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Location:
United States , Petaluma, CA

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Category:
Research and Development

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Contract Type:
Not provided

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Salary:

116000.00 - 159500.00 USD / Year
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Job Description:

The Scientist will join the Enzymatic and Metabolic In Vivo team to design and execute key in vivo studies focused on developing therapeutics to transform the lives of people with genetic metabolic disorders. The primary role of the Scientist will be in design and execution of in vivo studies as part of the Enzymatic and Metabolic In Vivo Team. They will work collaboratively across the Research and Early Development Department to identify, develop and execute project strategies for in vivo testing of novel therapeutics. Areas of focus will span from animal model development to testing novel therapeutic approaches for genetic metabolic disorders.

Job Responsibility:

  • Conduct research on genetic metabolic diseases
  • Contribute to novel therapeutic programs based on innovative, ground-breaking discoveries that could lead to new, high-impact opportunities for patients
  • Perform research and publish findings in high-impact journals and present research at major conferences
  • Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan
  • Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums
  • Write, review and contribute to study synopses, protocols, study reports and regulatory documents
  • Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects
  • Participate in multi-disciplinary drug development teams and may lead sub-teams
  • Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection
  • Provide daily care and monitoring of mice or rats, including health checks and documentation
  • Follow all institutional, local, and federal regulations regarding animal care and use
  • Adhere to safety protocols and maintain a clean and organized work environment
  • Maintain detailed and accurate records of all procedures and animal health status including adverse study events
  • Meticulous electronic lab notebook documentation
  • Communicate experimental plans and results to the project team
  • Support product development and regulatory filings for pivotal clinical studies
  • Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines
  • Share your knowledge and understanding with other team members
  • Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs
  • Willingness to work on site full time including off hours and weekends based on study needs

Requirements:

  • PhD in a related subject area with demonstrated in vivo research experience in metabolic disease
  • Postdoctoral or industry (2-5 years preferred) experience in genetic metabolic diseases
  • Extensive hands-on experience with rodent in vivo work in the metabolic field
  • Demonstrated experience in metabolic biology/disease research in academia or industry (preferred) including publication record
  • Strong analytical, problem-solving, and decision-making skills
  • Strong understanding of genetically engineered models, breeding, and management and Gene therapy modalities
  • Excellent oral and written communication skills
  • Passion for contributing your scientific skills to develop therapies for patients in need
  • Must be able to utilize computer databases for analysis, data entry, and point of care observations
  • Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams
  • Must be able to work with external regulatory agencies and accreditation groups
  • Some "off-core business hours" work required
  • Complete all company training requirement
  • Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks
  • This position is an on-site critical required position
What we offer:
  • Discretionary annual bonus
  • Discretionary stock-based long-term incentives
  • Paid time off
  • Company-sponsored medical, dental, vision, and life insurance plans

Additional Information:

Job Posted:
December 26, 2025

Employment Type:
Fulltime
Work Type:
On-site work
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