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BigHat Biosciences · Research and Development

Scientist II, Developability

United States, San Mateo 145000.00 - 165000.00 USD / Year · Job Posted June 15, 2026
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Job Description

BigHat Biosciences is looking for a hands-on, bench-driven scientist to drive antibody developability assessments that advance our Milliner Platform for AI-designed therapeutics. This is a primarily lab-based role where you'll spend the majority of your time at the bench executing and innovating on our developability workflows.

Job Responsibility

  • Lead developability R&D projects: design, optimize, and execute high throughput developability assays to expand BigHat's toolkit
  • Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization
  • Support late-stage characterization and IND-enabling studies, including formulation screening, stress testing, peptide mapping, and simulated administration studies, to rank and advance lead candidates
  • Serve as the Developability lead within project teams, guiding experimental strategy to address liabilities and hit program milestones
  • Work cross-functionally to automate and train colleagues on new and existing methods, build QC frameworks for monitoring assay performance, and adapt workflows to existing LIMS infrastructure
  • Proactively and independently analyze data, interpret scientific findings, propose next steps, and broadcast findings clearly across the organization

Requirements

  • PhD in Biochemistry or relevant discipline with 3+ year(s) of industry experience
  • exceptional non-PhD candidates with deep bench experience will be considered
  • Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS, including method development and optimization
  • Track record of translating complex data into clear results and recommended actions
  • Experience with protein structures and antibody engineering
  • Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost

Nice to have

  • Prior experience working in a dynamic start-up environment
  • Working as a project lead
  • Working with automation

What we offer

  • Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
  • Dental, and vision coverage through Guardian
  • Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
  • 401(k) with company match
  • DTO, two weeks of company-wide shutdown, and 12 company holidays
  • Paid parental leave
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