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Scientist 2, Separations and Biophysical Characterization

United States, Novato 118400.00 - 162800.00 USD / Year · Job Posted March 01, 2026
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Job Description

The Analytical Sciences group, part of the Technical Development & Services department at BioMarin Pharmaceutical Inc., is seeking a Scientist 2 for the Separations and Biophysics Assays team. This position will focus on biophysical method development and the characterization of protein-based therapeutics - enzymes, conjugated proteins, peptides, emphasizing biochemical and biophysical characterization of these molecules and their degradation products to support CMC product development across early, late-stage, and commercial assets. This includes structure function relationship, solubility profiles, thermodynamics/kinetics and interactions. The ideal candidate will demonstrate strong motivation, critical thinking abilities, effective communication skills, and experience working successfully in multidisciplinary, fast-paced environments. The candidate will be responsible for developing methods utilizing a range of biophysical techniques, including AUC, CD, DSC, DSF, DLS, ITC, SEC-FFF/MALS and other relevant technologies. Responsibilities also include managing sample testing, compiling test results, and effectively summarizing findings. The individual should demonstrate exceptional organizational, analytical, and communication abilities, and exhibit initiative and efficiency while collaborating in a dynamic, team-oriented environment.

Job Responsibility

  • Manage the development, optimization and implementation of biophysical characterization activities within Analytical Sciences for various protein-based therapeutics and other modalities
  • Design and conduct studies independently, including but not limited to assess protein structure, structure function relationship, protein-excipient compatibility, solubility, and binding kinetics and affinities
  • Use biophysical methods (AUC, CD, DSC, DSF, DLS, ITC, SEC-FFF/MALS) to analyze stability and solution properties for various therapeutics
  • Develop and qualify biophysical methods for products from early (pre-clinical) to commercial stages
  • Manage CDMO partnerships to implement analytical methods or troubleshoot if necessary
  • Troubleshoot and optimize methods
  • Provide quantitative analysis and interpretations
  • prepare protocols, reports, and maintain electronic records for inspections
  • Present data regularly to teams and leadership
  • Write technical reports summarizing study outcomes
  • Handle multiple projects and tight deadlines
  • Develop external collaborations to advance departmental capabilities

Requirements

  • PhD degree in Biophysics, Biochemistry, Chemistry or related discipline and minimum 5 years of relevant post graduate experience in the industry
  • Master’s degree in biochemistry or chemistry or related discipline and minimum 7 years of relevant post graduate experience in the industry
  • In-depth understanding of biophysical methods for protein structure and function, protein chemistry, small molecule or oligo chemistry structure, and function
  • Subject matter expertise in biophysical methods using AUC, CD, DSC, DSF, DLS, ITC, SEC-FFF/MALS, and other areas such as subvisible particulate characterization, microscopy
  • Knowledge in standard liquid chromatography methods (e.g. SEC, IEX, RP-HPLC), capillary electrophoresis (CE, cIEF) and detectors: UV, FLD, CAD, and ELSD
  • Experience in phase appropriate analytical development supporting drug substance (DS), drug product (DP) assays and supporting formulation development across both early and late phases
  • Collaborative skills to work in a cross-functional environment
  • Excellent writing skills including experimental documentation
  • Proven data analysis, interpretation and communication, collaboration and scientific communication skills
  • Proven flexibility and execution skills to deliver in a fast-paced, multi-tasking environment

Nice to have

  • CMC knowledge of pharmaceutical development of proteins, peptides, small molecule, gene therapy and/or oligo products and higher order structure characterization and interpretation of data
  • Experience in development of methods, designing of experiments using AUC, CD, DSC, DSF, DLS, ITC, SEC-FFF/MALS, and other related technologies
  • Experience in liquid chromatography using SEC, RPLC and capillary electrophoresis (CE, cIEF)
  • Excellent project management, verbal/written communication, and interpersonal skills
  • Prior management experience with ability to lead, mentor and manage direct reports on a daily basis

What we offer

  • company-sponsored medical, dental, vision, and life insurance plans
  • discretionary annual bonus
  • discretionary stock-based long-term incentives
  • paid time off

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