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The RNome Core is a facility core within the National Institute of General Medical Sciences (NIGMS) COBRE: Center for the RNA Biology in Health and Disease created to provide an integrative suite of RNA biology services and advice to PIs in Rhode Island who are studying RNA while also training the next generation of RNA biologists through courses/workshops.
Job Responsibility:
Establishing the RNome core to provide long-read sequencing for identifying new RNA species and mapping RNA modifications both globally and at single-molecule level in sequence context
Adding RNA biology functionality to integrate diverse existing cores allowing them to provide new RNA-related services (e.g., Identifying RBP occupancy and binding specificity, RNA visualization, RNA secondary structure analysis, RNA functional genomics, experimental design for RNA biophysical and structural analysis, facilitating data transfer to the Computational Biology Core)
Running a series of summer courses and workshops on RNA biology which will draw participants nationally and locally
Requirements:
PhD degree in genetics, genomics or molecular biology or related field plus 5-7 years relative experience
PhD graduate research experience in genomics and performing long read sequencing on RNA and DNA, ideally including mapping of RNA modifications
Relevant coursework and advanced knowledge of laboratory approaches and techniques in RNA biology
Strong computational biology skills
Prior experience mentoring younger researchers as will supervise a technician
Flexible availability to maintain and monitor 24/7 operation of Oxford Nanopore sequencer using remote access tools and in person if necessary and fixing problems as they arrive even outside of standard work hours
Excellent written and communication skills
Ability to be observant and self-motivated
Ability to think critically and problem-solve
Ability to work independently
Ability to communicate clearly and professionally with core facility users
Ability to complete accurate records and follow detailed instructions