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The Bernstein Laboratory answers fundamental questions about the epigenetic regulation of cellular state, and how these systems go awry in cancer. With this goal in mind, we have pioneered approaches to profile and perturb the epigenome, including at single cell resolution. We are looking for a highly motivated individual who will contribute to and lead research projects, think independently and make original intellectual contributions. Research technicians in our laboratory regularly present their own work and contribute to the writing of papers and grant applications. We view a research technician as a mentored training position, with a primary goal being the professional development of our technicians. Prior technicians have successfully pursued a variety of subsequent career directions including obtaining MDs, PhDs, MD-PhDs, and direct entry into industry. The successful candidate will join the team of Prof. Brad Bernstein working primarily with postdoctoral researcher Dr. Alba Rodriguez-Meira, and will also assist with general lab management when needed. Our group spans the Department of Cancer Biology at the Dana-Farber Cancer Institute, Harvard Medical School and the Broad Institute of MIT and Harvard, with extensive collaboration across these institutions. This position requires full-time on-site presence.
Job Responsibility:
Plan, execute and troubleshoot genomic assays and gene editing protocols, including next generation sequencing, CRISPR-Cas9 editing, primary cell culture and other specialized protocols
Conducts analysis and interpretation of observed results, including computational analysis of genomic datasets using established pipelines in R, python and HPC
Write reports and summaries of findings, including grant preparation and presentations, and look for opportunities to co-author publications. May be expected to participate in formal and information presentations of results
Expected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications
Maintain detailed notebook of all work-related activities
Performs standard experimental procedures, maintain lab reagents and equipment, chemicals and sample databases
Clean, maintain and prepare equipment, supplies and work areas. May be responsible for ordering of supplies, collaborate with Purchasing and may be responsible for negotiating with vendors
Monitor laboratory work to ensure compliance with Environmental Health and Safety information, follow and improve the standard operation procedures specific to each laboratory
May be responsible for collecting biological specimens to detect the presence of disease or other problems
Requirements:
Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred
Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff
Ability to analyze information and use logic to address work-related issues and problems
Must have attention to detail and be thorough in completing work tasks
Ability to work within a team environment
The position requires a bachelor’s degree, preferably in biology or chemistry, with no prior professional experience necessary