Research Technician - Viral Neuropathogenesis, CSIRO

CSIRO

Location:
Australia, Geelong

Category:
Research and Development

Contract Type:
Employment contract

Salary:

96000.00 - 109000.00 AUD / Year

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Job Description:

The role involves performing experimental validation and testing of novel protein derivatives in human and mouse ex-vivo neuronal model systems to generate therapeutic efficacy data for patent application and enable the selection of candidates for future pre-clinical trials in animal models.

Job Responsibility:

Carrying out pre-determined experiments to test the efficacy of selected proteins to reduce neurodegeneration in ex-vivo models
Isolating and culturing mouse primary neurons from embryos to establish a ex-vivo mouse neuronal system for testing the efficacy of the protein derivatives
Generating and maintaining 2D, 3D human stem cell-derived neuronal model systems for testing the efficacy of the protein derivatives
Generating recombinant lentiviruses from plasmids using specific cell lines, which would be used for the expression of peptide therapeutics in human and mouse neurons
Efficiently handling synthetic peptides and performing peptide dose response assays in ex-vivo neuronal cultures
Performing immunocytochemistry, confocal microscopy, western blotting, protein interactome analysis using coprecipitation, ELISA and molecular biology including qPCR assays in neuronal culture samples
Applying computational skills, including statistical and imaging software, to quantify data from microscopy and other biochemical assays
Operate under laboratory guidelines relevant to high containment laboratories (up to PC3 level) and under SSBA, OGTR and Department of Agriculture regulatory frameworks

Requirements:

Tertiary qualifications in biomedical science or other relevant field, or equivalent relevant work experience
Demonstrated experience in performing experimental research, including planning, implementing, and completing research projects within defined timelines
Experience in sterile cell culture techniques and the ability to adapt this expertise for working with ex-vivo neuronal model systems
Experience in working in a high-containment laboratory, including demonstrated ability to operate within national and institutional compliance frameworks
Experience in basic classical virology techniques, viral cultures, and viral quantification methods
Demonstrated experience in data analysis and writing or compiling data for scientific reports

Nice to have:

Experience in light microscopy techniques, including confocal/epifluorescence microscopy and immunostaining
Experience in biochemical assays, including western blotting
Experience in molecular biology skills including plasmid cloning, amplification and recombinant virus generation from plasmids
Experience in handling and maintaining neural or primary cell cultures

What we offer:

Up to 15.4% superannuation
Flexible working arrangements
Range of leave entitlements
Career development opportunities

Additional Information:

Job Posted:
May 26, 2025

Expiration:
June 22, 2025

Employment Type:

Fulltime

Work Type:

On-site work

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Research Technician - Viral Neuropathogenesis