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The peptide chemistry unit is seeking a talented peptide chemist with a strong background in peptide & macrocycle chemistry, as well as expertise in organic synthesis. The successful candidate will be passionate about conducting high-quality scientific research to advance internal and external peptide drug discovery programs. The candidate will be involved in the design of new molecules to progress structure-activity relationship studies and in the planning and execution of multi-step syntheses, purification, and analytical characterization of complex peptides to achieve agreed-upon objectives in a timely manner. The successful candidate will communicate effectively with internal and external collaborators and will work efficiently in a multi-disciplinary team environment.
Job Responsibility:
Develop and execute synthetic strategies towards complex molecules using state-of-the-art synthetic methodologies
Analyze and identify compounds using different purification and spectroscopic techniques
Contribute to the design of peptides with improved potency and physiochemical properties to advance programs according to scientific strategies and goals within a project team setting
Present data and reports on project status at internal and external meetings
Conduct laboratory operations in a safe manner
Exhibit safety awareness and safe work practices
comply with all safety requirements according to Italian laws
Requirements:
Master of Science Degree (Laurea Magistrale) in Chemistry with 5 years of experience doing peptide chemistry in a pharmaceutical or biotech environment
PhD in Chemistry with one or more relevant postdoctoral experiences or with experience in a pharmaceutical or biotech environment
In/depth knowledge of peptide chemistry
Expertise in design and synthesis of complex peptides, including peptide conjugates, macrocycles, and small proteins
Mastery of use of laboratory equipment with a preference for knowledge on the use of peptide synthesizers
Design and execution of synthetic routes for the synthesis of amino acids and building blocks
Excellent knowledge of common purification techniques (HPLC, IEX, GPC) and analytical techniques (UPLC/HPLC and mass spectrometry)
Knowledge in structure elucidations of organic molecules by NMR and MS
Outstanding organizational skills
Excellent communication skills, both verbal and written
Good knowledge of English is mandatory
Ability to productively work in teams
Nice to have:
Experience in the discovery of therapeutic peptides in an industrial environment will be considered a plus
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