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Wellcome Trust–funded project investigating how RNA interference (RNAi) regulates Candida albicans adaptation to host environments and contributes to the commensal‑to‑pathogen transition. The role is highly collaborative, contributing to a multidisciplinary effort to uncover how RNAi coordinates chromatin structure, genome stability and transcriptional responses during adaptation.
Job Responsibility:
Lead experimental work integrating (epi)genomics and genetics approaches to determine how RNAi shapes genome organisation and interacts with other epigenetic processes to facilitate fungal adaptation
Conduct chromatin‑profiling experiments such as ChIP‑seq and ATAC‑seq
Perform Hi‑C analysis in wild‑type and RNAi‑defective strains under different host‑relevant gut conditions
Investigate how RNAi contributes to reversible, non‑DNA‑encoded regulation of gene expression
Employ molecular genetics to generate and analyse RNAi mutants
Work alongside the team’s bioinformatician to design optimal genomics and epigenomics strategies
Contribute to scientific publications
Prepare conference presentations and share findings at national and international meetings
Support other lab members, troubleshooting and collaborative data interpretation
Requirements:
PhD in Genetics, Molecular Biology or related disciplines
Strong understanding of RNAi biology
Excellent understanding of epigenetics
Practical experience with genetic manipulation, including generating mutants and conducting functional assays
What we offer:
Family, faith and diversity friendly working arrangements