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Seeking an AI‑driven Research Scientist to push the boundaries of immuno‑oncology and next‑gen biologic design. Proclinical is seeking a Research Scientist specializing in AI and Machine Learning to support innovative advancements in immuno-oncology and pharmaceutical research.
Job Responsibility:
Design and implement advanced AI/ML approaches for antibody discovery, including fine-tuning protein language models and generative protein design workflows
Develop scalable machine learning methods for multi-objective optimization of biologics such as antibodies, antigens, ADCs, and other modalities
Build sequence-aware predictive models to prioritize ASO designs based on exon-skipping responses across diverse targets and modalities
Create reproducible computational frameworks for biologics, encompassing data ingestion, feature engineering, model training, validation, and deployment
Curate and harmonize datasets, defining robust sequence and structure features to drive model performance
Establish benchmarks and collaborate with experimental teams to validate predictions
Evaluate and adopt tools to enhance modeling workflows and decision support systems
Maintain a clean, well-documented codebase and provide user guidance for cross-functional teams
Perform additional related tasks as assigned
Requirements:
PhD in Computational Chemistry/Biology, Machine Learning, Biomedical/Chemical Engineering, or a related field
Strong background in oligonucleotide chemistry and antibody design
Proven experience in computational modeling of antibody-antigen interactions
Expertise in probabilistic learning, deep learning models (e.g., RNNs, GNNs, Transformers), and generative AI
Proficiency in programming languages such as Python, R, and SQL, with hands-on experience in frameworks like PyTorch, TensorFlow, or JAX
Experience developing machine learning models for DNA, RNA, and proteins, including language models and structure prediction
Familiarity with large-scale computing, cloud infrastructures, and database systems
Knowledge of tools like AWS, GitHub/GitLab, and Docker containers
Strong communication skills to collaborate effectively with multidisciplinary teams