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The Wu Laboratory at Wake Forest University School of Medicine is seeking highly motivated individuals for full time Technician positions to join our dynamic team focused on the molecular mechanisms of inflammation in brain tumor/metastasis and neurodegenerative diseases. Our research investigates cellular signaling between immune cells and tumors, with a focus on developing targeted therapies for brain metastasis and brain tumors. We employ cutting-edge techniques such as single-cell sequencing, CRISPR-Cas9 genome editing, and immune cell therapy against brain tumors. Under direct supervision from a higher level technician or a principal investigator, performs a variety of moderately complex and generally standardized physical, chemical, or biological tests with procedures and techniques previously outlined by established protocols and other scientific data. Provides direction and guidance to lab staff.
Job Responsibility:
Conducts generally standardized chemical, physical, and biological tests on experimental/clinical materials
Performs micro-analysis, lipids analysis, enzyme studies, and chromatographic studies on various types of tissues, secretions, and excretions
Conduct laboratory experiments, including cell culture, immunoassays, and molecular biology techniques (e.g., PCR, Western blotting, cell transfection, immunoprecipitation, immunofluorescence staining, protein purification, BiFC assay, flos cytometry, MTS, plasmid extraction, CRISPR-Cas9 genome editing)
Assist in animal studies, including mouse models for brain metastasis and behavioral testing
Sets up equipment and organizes materials used in performing scheduled tests, experiments, and/or operations
Selects the appropriate experimental/clinical format from established standard formats and prepares simple charts, graphs, and reports from data obtained during research experiments and observations of research subjects
Isolates and identifies various microorganisms through established laboratory techniques
Develop and test novel therapeutic strategies, including engineered immune cell-based tools for brain metastasis
Data analysis using the software of Prism, ImageJ, Zen Blue, 10X Genomics, GEO, TCGA
Trains and demonstrates to graduate students, medical students, and other technical personnel, a variety of technical procedures
Takes blood samples, pressures, and other specimens and measurements as required by research/clinical protocols. Inoculates research animals with various pathogens and performs minor animal surgery
Collects tissues and specimens for laboratory analysis
obtains samples, prepares, mounts, and stains tissue, blood, and other substances for microscopic examinations
Reviews scientific journals, abstracts, and other publications for information applicable to research projects
Performs other related duties incidental to the work described herein.
Requirements:
Bachelor's degree in Biology, Chemistry, Zoology, or other related science, or high school diploma with four years of related clinical/ research experience
Prior laboratory experience in molecular biology, cell culture, or animal studies is preferred
Strong organizational skills and attention to detail
Ability to work independently and as part of a collaborative team
Excellent communication skills for documenting and presenting research findings
Ability to listen and communicate effectively
Basic computer skills
Knowledge of medical terminology to interact with medical staff regarding laboratory procedures and result
Knowledge of medical equipment and instruments
Knowledge of common safety hazards and universal precautions to establish a safe work environment.
What we offer:
Paid Time Off programs
Health and welfare benefits such as medical, dental, vision, life, and Short- and Long-Term Disability
Flexible Spending Accounts for eligible health care and dependent care expenses
Family benefits such as adoption assistance and paid parental leave
Defined contribution retirement plans with employer match and other financial wellness programs