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The Clinical Trials Research Nurse is a registered professional nurse responsible for coordinating and conducting clinical research studies involving human subjects in compliance with national regulations, Good Clinical Practice (GCP) guidelines, institutional policies, and sponsor protocols. This role supports Phase I–III clinical trials and ensures the safety, rights, and well-being of research participants while maintaining high standards of data integrity and regulatory compliance. The Clinical Trials Research Nurse works collaboratively with principal investigators, research coordinators, sponsors, and multidisciplinary healthcare teams to facilitate study implementation, subject recruitment, clinical procedures, monitoring, and ongoing participant care.
Job Responsibility:
Direct participant care, protocol-required procedures, monitoring for adverse events, specimen collection, and clinical assessments
Maintain accurate and complete source documentation in accordance with GCP and federal regulations
Perform quality assurance reviews to ensure consistency between source documents and case report forms (CRFs)
Screening, informed consent, eligibility reviews, outreach, and participant education
Source documentation, AE/SAE reporting, audit preparation, and regulatory submissions
Team meetings, protocol adherence monitoring, workflow optimization, and performance improvement initiatives
Data entry, filing, scheduling, inventory control, and study material management
Sponsor training, GCP certification, and continuing education
Conduct protocol-specific clinical procedures including venipuncture, ECGs, nasal swabs, urine collection, specimen processing, and vital sign monitoring
Perform structured and unstructured interviews to assess subject eligibility, clinical status, and adverse reactions
Monitor research participants for local and systemic reactions and document adverse events (AEs) and serious adverse events (SAEs)
Ensure timely reporting of AEs and SAEs to sponsors, Institutional Review Boards (IRBs), and regulatory authorities
Identify potential subject pools through clinic settings, community outreach, and referral sources
Conduct screening and eligibility assessments via in-person and telephone evaluations
Obtain and document informed consent ensuring participant comprehension and voluntary participation
Provide ongoing education to participants and families regarding study requirements, risks, and benefits
Monitor for protocol deviations and implement corrective actions as needed
Assist with audits and inspections by sponsors and regulatory authorities
Participate in study team and sponsor meetings throughout the trial lifecycle
Collaborate with investigators and research staff to improve site performance and data quality
Contribute to process improvement initiatives to enhance participant safety and study efficiency
Track participant visits and prepare compensation requests
Manage inventory of study supplies and maintain organized exam and research areas
Support data entry, filing, correspondence, and development of study-related documentation
Assist with compiling study metrics and reports as required
Requirements:
Associate Degree in Nursing (ADN) required
Active Registered Nurse (RN) license in the practicing state and/or compact license
Minimum of 1 year clinical nursing experience
clinical trials experience preferred or a combination of education and experience
Proficiency in phlebotomy and adult patient care
Strong interpersonal, communication, and organizational skills
Competency in electronic medical records and research databases
Nice to have:
Bachelor of Science in Nursing (BSN) preferred
Knowledge of clinical research protocols and regulatory frameworks
Ability to work independently and manage multiple priorities
Strong critical thinking and problem-solving abilities
Attention to detail with high standards of accuracy
Experience with data collection and clinical documentation systems