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This is an outstanding opportunity for a Research Associate, with a background in imaging the cerebral vasculature in mouse models of Alzheimer’s disease, to work within the Brain Inflammation and Microvascular@Manchester groups under the supervision of Dr Kira Shaw and Dr Ingo Schiessl. The post holder will be based in the Division of Neuroscience. This innovative project will involve the use of in vivo imaging approaches to assess neuronal and vascular function in the hippocampus and neocortex of awake mice.
Job Responsibility:
Investigate the effects of menopause on neurovascular health using preclinical mouse models of Alzheimer’s disease (AD) and AD risk
Use in vivo imaging approaches (e.g. multi-photon microscopy and optical imaging spectroscopy) to assess neuronal and vascular function in the hippocampus and neocortex of awake mice
Assess cognitive function using established behavioural tests
Conduct post-mortem analysis including immunohistochemistry and RNA sequencing to identify candidate treatments targeting menopause-sensitive vasodilation pathways
Requirements:
Background in imaging the cerebral vasculature in mouse models of Alzheimer’s disease
Excellent preclinical imaging skills
Experience of imaging the cerebral vasculature in vivo is essential
Ability to work with minimal supervision
What we offer:
Fantastic market leading Pension scheme
Excellent employee health and wellbeing services including an Employee Assistance Programme
Exceptional starting annual leave entitlement, plus bank holidays
Additional paid closure over the Christmas period
Local and national discounts at a range of major retailers