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Perform physicochemical, histological, mechanical, and structural characterisation of decellularised tissue membranes and hybrid constructs supplied by industrial partner
Conduct biological validation across dermal and tendon repair models, including fibroblast, keratinocyte, tenocyte, and tendon-derived cell viability, proliferation, attachment, and migration assessments
Execute in vitro wound healing assays including scratch assay and transwell migration studies to evaluate wound closure kinetics and re-epithelialisation potential
Assess tenogenic differentiation including gene expression profiling of tendon-specific markers and collagen fibril alignment analysis
Perform ECM proteomic profiling and pro-tenogenic secretome analysis across construct systems
Requirements
PhD (or near completion) in biomaterials, biomedical engineering, tissue engineering, materials science, or a closely related discipline
Hands-on experience in mammalian cell culture, including primary cells or established cell lines relevant to dermal or musculoskeletal biology
Demonstrated experience in biomaterials characterisation including mechanical testing, rheology, and spectroscopic methods
Practical experience with histological techniques (e.g. H&E, Masson's trichrome, immunostaining)
Experience with cell viability assays, proliferation assays, and migration assays (scratch assay, transwell)
Nice to have
Experience with decellularisation techniques or characterisation of extracellular matrix scaffolds
Familiarity with ECM proteomic analysis, including sample preparation for mass spectrometry
Experience with tenogenic or dermal fibroblast differentiation models
Track record of peer-reviewed publications and/or conference presentations
What we offer
Generous employer contribution pension
29 days annual leave plus bank holidays, along with Christmas closure