Research Associate I / II - Biologics Purification & Characterization

• Perform purification of recombinant enzymes and other therapeutic biologics, including proteins, antibodies, and peptides, using standard chromatography systems
• Execute purification workflows including: Affinity chromatography
• Ion exchange chromatography (AEX/CEX)
• Size-exclusion chromatography (SEC)
• Hydrophobic interaction chromatography (HIC)
• Desalting and buffer exchange
• Perform concentration and buffer exchange using tangential-flow filtration (TFF) or centrifugal filtration
• Prepare buffers and reagents according to established protocols
• Support routine equipment checks, basic instrument maintenance, and troubleshooting as needed
• Perform analytical assays to assess purity, identity, and concentration of biologics, including: SDS-PAGE, CE-SDS
• SEC-HPLC, RP-HPLC
• UV/Vis spectrophotometry
• Other established protein or peptide analytical methods as required
• Execute established methods with an emphasis on data quality, reproducibility, and documentation
• Assist with basic data analysis and communication of results to project teams
• Maintain accurate and complete electronic and/or paper laboratory notebooks
• Follow established SOPs and document deviations with guidance
• Communicate results, observations, and progress updates clearly within the team
• Contribute to a safe, clean, and well-organized laboratory environment in compliance with BioMarin safety standards

• Bachelor’s degree in Biochemistry, Biology, Chemical Engineering, or a related discipline
• 0–2 years of relevant hands-on laboratory experience (academic or industry) for Research Associate I
• Bachelor’s degree with 2+ years of relevant experience, or Master’s degree with 1–2 years of relevant experience for Research Associate II
• Prior experience with biologics purification (enzymes, proteins, antibodies, or peptides) strongly preferred
• Experience with FPLC/HPLC and common protein analytical techniques is highly desirable
• Familiarity with AKTA Pure/Avant or similar chromatography instrumentation
• Strong attention to detail, organization, and reliable documentation practices
• Ability to follow established workflows and troubleshoot with guidance
• Effective communication and collaboration skills
• Working knowledge of Microsoft Office
• familiarity with data analysis tools (e.g., GraphPad Prism, JMP) is a plus

Familiarity with data analysis tools (e.g., GraphPad Prism, JMP)

• Discretionary annual bonus
• Discretionary stock-based long-term incentives
• Paid time off
• Company-sponsored medical, dental, vision, and life insurance plans