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BigHat Biosciences · IT - Software Development

Research Associate I, CFPS Production

United States, San Mateo 75000.00 - 88000.00 USD / Year · Job Posted June 17, 2026
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Job Description

BigHat Biosciences is seeking a self-motivated individual for a Research Associate, CFPS Production role to manufacture, validate and execute experiments to develop cell-free protein synthesis (CFPS) reagents for BigHat’s high-throughput, automated platform for producing and characterizing antibodies.

Job Responsibility

  • Manufacture and validate CFPS reagents used in BigHat’s high-throughput antibody screening platform including making buffers, media for biomass production and performing QC experiments on reagents
  • Maintain CFPS reagent manufacturing equipment including incubators, centrifuges, and homogenizers
  • Coordinate with lab ops team to request/order supplies for CFPS reagent manufacturing to ensure reliable stock for platform
  • Design and run experiments for development of next generation CFPS extract to optimize yield and purity of next generation antibodies on our platform
  • Keep a detailed record of all experiments using BigHat’s documentation tools, and clearly communicate results and challenges
  • Present experimental plans and results during regular meetings with manager and science teams.

Requirements

  • B.S. degree in Biochemistry, Molecular Biology, or related field with 1-2 years of industry experience
  • Experience working with recombinant protein expression from bacterial cultures
  • Experience with molecular cloning techniques including primer design, PCR, mutagenesis, Golden Gate Assembly
  • Excellent communication skills
  • organized and works well in small groups.

Nice to have

  • Experience with CFPS
  • Experience and knowledge of protein purification methods including affinity chromatography and SEC
  • Experience with quantitative and/or statistical analysis software (e.g. Excel, GraphPad Prism, Python, R, etc.)
  • Experience with automation and high-throughput tools and robotic instrumentation.

What we offer

  • Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
  • Dental and vision coverage through Guardian
  • Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more
  • 401(k) with company match
  • DTO, two weeks of company-wide shutdown, and 12 company holidays
  • Paid parental leave.
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