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We are seeking a motivated Research Associate I with in vivo experience to join the Skeletal and CNP Therapeutic Area group in vivo team to design and execute key studies to transform the lives of people with rare musculoskeletal diseases. The primary role of the Research Associate I will be assisting with the execution of in vivo studies as part of the in vivo team. They will work collaboratively across Research group in the Skeletal and CNP Therapeutic Area group as well as other therapeutic areas as needed to execute project strategies for in vivo testing of novel therapeutics.
Job Responsibility:
Conduct in vivo dosing support and execution of studies including IV, IM, SC, IP, and PO dosing for research on genetic skeletal diseases and CNP therapeutic indications
Contribute to novel therapeutic programs
Participate and collaborate in writing, review and contribution to study synopses, protocols, study reports and regulatory documents
Collaborate with various BioMarin functions to collaboratively ensure timely progression of projects
Execute hands-on responsibilities including animal handling and restraint (rodents), administration via various routes of administration, in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection
Provide daily care and monitoring of mice or rats, including health checks and documentation
Follow all institutional, local, and federal regulations regarding animal care and use
Adhere to safety protocols and maintain a clean and organized work environment
Maintain detailed and accurate records of all procedures and animal health status including adverse study events
Meticulous electronic lab notebook documentation
Communicate experimental plans and results to the project team
Support product development and regulatory filings for pivotal preclinical studies
Follow instructions and work independently to effectively manage time and prioritize tasks to ensure all assignments are completed on or before deadlines
Share knowledge and understanding with other team members
Document experimental methods and outcomes using Electronic Lab Notebooks and generation/maintenance of technical procedure documents and SOPs
Willingness to work on site full time including off hours and weekends based on study needs
Requirements:
Bachelor’s or equivalent scientific degree in Biology or related science
Hands-on experience with dosing and data collection in animal models of disease
Proficiency with in vivo methods such as administration of test articles, perfusion and tissue collection, blood collection
Rodent surgical experience preferred
Minimum of 2 years relevant experience
Strong analytical, problem-solving, and decision-making skills
Understanding of genetically engineered models, breeding of rodents
Excellent oral and written communication skills
Must be able to utilize computer databases for data analysis, data entry, and point of care observations
Must be able to work under time constraints with minimal direction of day-to-day responsibilities, including collaboratively working with multidisciplinary teams
Must be able to work with external regulatory agencies and accreditation groups
Complete all company training requirements
Perform all work per designated safety standards and comply with Personal Protective Equipment requirements and occupational health to perform work tasks
Nice to have:
Experience with rodent in vivo models of disease
Experience with skeletal disease biology
Some industry experience
Experience with other in vivo analytic techniques including gait analysis, mechanical evaluation of bone, histology, computerized tomography and IVIS imaging
What we offer:
Discretionary annual bonus
Discretionary stock-based long-term incentives
Paid time off
Company-sponsored medical, dental, vision, and life insurance plans
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