Research assistant in cancer genomics and therapeutics

The Sheltzer Lab at Stanford University is seeking a research assistant for a cutting-edge project applying CRISPR to study aneuploidy in cancer. Aneuploidy is a state in which cells have gained or lost entire chromosomes. Nearly 90% of cancers are aneuploid, though the causes and consequences of this condition are poorly understood. The Sheltzer Lab develops and applies chromosome engineering methodologies to dissect cancer aneuploidy at a cellular level. These approaches have revealed multiple unexpected ways that aneuploidy affects cancer physiology and indicate that aneuploidy plays a central role in driving malignant growth. We aim to leverage our understanding of aneuploidy to uncover genetic vulnerabilities unique to aneuploid cancers, which could be exploited for therapeutic development.