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The Alt Lab is seeking a highly motivated and detail-oriented individual for a Research Assistant III role. Our Alt lab investigates the molecular mechanisms underlying V(D)J recombination, class switch recombination, and somatic hypermutation in developing and activated B lymphocytes. We apply these insights to generate mouse models that support HIV-1 research, vaccine development, and antibody-based therapies. This role combines hands-on experimental work with technical expertise, regulatory compliance, and leadership responsibilities, including management of lab operations, mentoring junior staff, and maintaining adherence to institutional protocols.
Job Responsibility:
Perform advanced embryo manipulation techniques, including microinjection of pre-implantation embryos with mouse stem cells and aseptic surgical transfer to the uterus or oviduct
Generation and maintenance of transgenic and knockout mouse models in a barrier-level facility
Maintenance of mouse colonies, including specialized care for immunodeficient models
Troubleshoots procedures if experimental results are unexpected or quality of specimens is poor
Independently decides which techniques may be appropriate for specific experimental investigations and carries out those experiments with minimal supervision or independently
Critically evaluates experimental results independently and provides summaries or interpretation of results to PI
Coaches RA I and RA II, interns, Co Ops on basic lab techniques
Calculates, graphs and compiles data obtained, maintaining records and logs of work performed
uses computer to perform statistical analyses
Requirements:
Bachelor’s Degree in STEM or Psychology
Master’s preferred
Bachelor’s degree and 3 years of relevant experience OR Master’s and 1 year of relevant experience
Experience with mouse embryonic stem cell culture and derivation is a plus
Nice to have:
Experience with mouse embryonic stem cell culture and derivation
What we offer:
flexible schedules
affordable health, vision and dental insurance
child care and student loan subsidies
generous levels of time off
403(b) Retirement Savings plan
Pension
Tuition and certain License and Certification Reimbursement