Process Development Senior Scientist Job at Amgen (Cambridge)

Process Development Senior Scientist

Join Amgen's Mission of Serving Patients. At Amgen, if you feel like you're part...

Location

United States , Cambridge

Salary:

123777.00 - 167463.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Doctorate degree PhD OR PharmD OR MD and relevant post-doc where applicable completed by August 2026
OR Master's degree and 3 years of Scientific experience
OR Bachelor's degree and 5 years of Scientific experience

Job Responsibility

Design and develop synthetic routes and scalable chemical processes for the manufacture of synthetic and hybrid drug substances
Develop safe, robust, efficient, and cost-effective manufacturing processes suitable for clinical and commercial production
Advance enabling technologies that accelerate pharmaceutical development and improve sustainability, efficiency, and process robustness
Support cGMP manufacturing activities and assist with technology transfer efforts to internal manufacturing sites and external contract manufacturing organizations (CMOs)
Build process understanding through experimentation, process characterization, modeling, and data analysis to ensure consistent process performance
Contribute to cross-functional drug substance development teams by providing technical expertise, experimental data, scientific recommendations, and clear documentation
Collaborate across disciplines to support regulatory filings and author technical sections of regulatory documentation
Stay current with advances in synthetic organic chemistry, process chemistry, and related technologies, and apply new scientific insights to ongoing programs
Effectively collaborate within multidisciplinary teams that include chemists, engineers, analytical scientists, and other technical experts
Independently manage project activities and deliver high-quality results within established timelines

What we offer

Health and welfare plans for staff and eligible dependents
Financial plans with opportunities to save towards retirement or other goals
Work/life balance
Career development opportunities
Retirement and Savings Plan with generous company contributions
Group medical, dental and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Stock-based long-term incentives

Fulltime

Process Development Senior Scientist - Drug Product Technologies

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part...

Location

United States , Thousand Oaks

Salary:

126066.05 - 170559.95 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
OR Master’s degree and 3 years of Scientific experience
OR Bachelor’s degree and 5 years of Scientific experience

Job Responsibility

Work effectively in a fast-paced, matrixed environment, collaborating across process development, research, regulatory, and manufacturing teams to advance programs and communicate technical recommendations to both scientific peers and leadership
Plan and execute formulation and fill/finish process studies for early-stage programs
Develop and characterize liquid and lyophilized formulations for biologics, with particular emphasis on ADC drug product formulation, handling, and lab-scale sterile filling
Build process understanding across unit operations to support scalable drug product development
Evaluate in-use compatibility and drug product stability under clinical conditions
Investigate ADC- and biologics-relevant CQAs (e.g., aggregation, fragmentation, drug-to-antibody ratio, free payload, charge/size variants, subvisible particles, surface interactions) to inform formulation and process design decisions
Leverage high-throughput tools for formulation screening and processability assessments
Identify and address technology gaps impacting ADC stability, linker-payload integrity, protein-excipient interactions, and process-related stress responses
Apply machine learning, AI, and data science to predictive modeling, workflow acceleration, and decision-making
Ensure development approaches are phase-appropriate, from discovery through clinical manufacturing

What we offer

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible

Fulltime

Process Development Senior Scientist - Synthetic Peptides, Oligonucleotides, ADCs

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part...

Location

United States , Thousand Oaks

Salary:

126066.05 - 170559.95 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
OR Master’s degree and 3 years of Scientific experience
OR Bachelor’s degree and 5 years of Scientific experience

Job Responsibility

Work effectively with a diverse team of synthetic chemists, chemical engineers and analytical chemists to invent synthetic routes and develop safe, robust, sustainable and cost-effective processes for antibody drug conjugate, peptide antibody conjugates, synthetic peptides and/or oligonucleotide manufacturing
Drive technology innovation in the synthesis, purification, and characterization of bioconjugates, oligonucleotides, and/or synthetic peptides
Support cGMP manufacturing and technology transfer to our internal manufacturing facilities and external contract manufacturers
Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency
Ensure process performance through process understanding, modeling and characterization
Contribute to drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc
Work cross-functionally to deliver regulatory documents and support regulatory filings
Serve as a technical expert and keep current in the field of bioconjugation, antibody drug conjugate, oligonucleotide, peptide, and process chemistry and manufacturing
Work independently in advancing projects and studies within required deadlines

What we offer

Health and welfare plans for staff and eligible dependents
Financial plans with opportunities to save towards retirement or other goals
Work/life balance
Career development opportunities
Retirement and Savings Plan with generous company contributions
Group medical, dental and vision coverage
Life and disability insurance
Flexible spending accounts
Discretionary annual bonus program
Stock-based long-term incentives

Fulltime

Process Development Senior Associate

At Amgen, if you feel like you’re part of something bigger, it’s because you are...

Location

United States , Cambridge

Salary:

85306.00 - 103484.00 USD / Year

Amgen

Expiration Date

Until further notice

Requirements

Master’s degree or (foreign equivalent) in Chemical Engineering, Bioengineering, Analytical Chemistry, Biochemistry or a related field & completion of a university-level course, research project, internship, thesis, or one year of experience in the following: 1. Analytical chemistry experience for small molecules, and completion of project deliverables including: designing and conducting targeted metabolomics experiments, extracting and analyzing results via dedicated software: ChemStation, MassHunter, or MassAnalyzer
2. Analytical method development (chromatography and mass spectrometry), related technologies and instrumentation including: U/HPLC, GC, or LC-MS
3. Method qualification and transfer for analytical instruments, along with data analysis and statistical evaluation of experimental results
4. Application analytical instrument troubleshooting across different platforms: Waters, Agilent, or Sciex, and problem solving of such technologies
5. Implementing Standard Operating Procedures in a laboratory environment in accordance with GLP standards
and 6. Maintaining a laboratory notebook.

Job Responsibility

Conduct experiments, analyze results, and implement process improvements to enhance efficiency and product quality
Design, develop, and optimize manufacturing processes
Collaborate closely with a team of analysts and scientists
Responsible for the technical aspects of developing analytical tools to gain understanding of quality attributes in product and process for late phase synthetic small molecule, synthetic peptide, and siRNA programs
Utilize platform and in-depth product attribute knowledge to advance Amgen products and ensure success through pivotal clinical phases to marketing authorization application
Develop, optimize, and execute analytical methods for synthetic small molecules, synthetic peptide, and SiRNA release testing and process characterization
Collaborate closely with drug substance process development team to achieve project objectives and provide analytical data to support drug substance product development.

What we offer

stock
retirement
medical
life and disability insurance
eligibility for an annual bonus
Retirement and Savings Plan with generous company contributions
group medical, dental and vision coverage
life and disability insurance
flexible spending accounts
discretionary annual bonus program

Fulltime

Senior Scientist- Process Chemistry

10x is looking for an outstanding Senior Scientist to join the Process Developme...

Location

United States , Pleasanton

Salary:

158400.00 - 214400.00 USD / Year

10x Genomics

Expiration Date

Until further notice

Requirements

Ph.D. in Chemical Engineering, Organic Chemistry, Polymer Chemistry, Surface Chemistry, and 4+ years of industry experience
Ability to integrate a broad range of scientific and engineering disciplines
Ability to design meaningful experiments and in-depth analysis of results
Experience using statistical tools for process control
Good documentation skills and ability to communicate experimental design, results and plans through presentations and reports
Understanding of physical chemical principles to scale up chemical manufacturing processes
Ability to develop, validate and transfer processes to manufacturing or OEM vendors
Strong collaboration and communication skills
Desire to be part of a rapidly evolving organization, with a compelling technology, and taking products and processes to the next level

Job Responsibility

Act as a technical lead to develop, optimize and support a broad range of chemistry-based production processes through use of custom equipment, optical imaging, and analytical testing
Develop a deep understanding of the interplay between chemistry, microfluidics, production processes, and molecular biology to identify the root cause of product deviations, troubleshoot them, and identify and implement solutions
Plan and execute experiments, maintain an accurate record of experimental details, in-depth data analysis, and clear communication of these results through documentation and presentations
Write protocols, develop procedures, and maintain accurate records
Communicate and present results clearly and contribute data for making critical design decisions
Job may require 10% international travel

What we offer

Equity grants
Comprehensive health and retirement benefit programs
Annual bonus program or sales incentive program
Competitive and comprehensive health benefits package
Easy-to-use benefits that promote wellbeing
Family friendly policies like parental leave
Generous time off

Fulltime

Senior Principal Scientist: Process Chemistry

Lead the chemistry behind tomorrow's medicines by driving world‑class drug subst...

Location

United States , Palo Alto

Salary:

Not provided

Proclinical

Expiration Date

Until further notice

Requirements

Ph.D. in Organic Chemistry with 8+ years of relevant industry experience in process chemistry
Strong expertise in synthetic chemistry, scale-up, and cGMP manufacturing
Working knowledge of QbD principles, PAT, risk management, and regulatory expectations
Proven experience managing CDMOs and CROs
Demonstrated ability to operate independently and influence cross-functional teams in a fast-paced development environment
Excellent problem-solving, communication, and project management skills
Up to ~20% travel, primarily to CDMO sites

Job Responsibility

Serve as the technical point of accountability for drug substance programs, ensuring alignment across CMC, Quality, Regulatory, and external partners
Lead route selection, process development, optimization, and impurity control strategies
Lead and manage CDMOs from proposal evaluation and selection through GMP manufacturing, release, and delivery
Characterize drug substance properties and support form selection activities
Review and approve batch records and oversee external manufacturing quality and compliance
Troubleshoot process issues and drive continuous improvement initiatives with internal and external teams
Prepare comprehensive tech transfer packages and support analytical method development
Guide chemical development strategy from early-stage programs through commercialization
Author and review technical sections for IND, IMPD, and other global regulatory submissions
Partner with Project Management and Finance to support cost, timeline, and risk management for drug substance programs

Senior Scientist, Diagnostic Assay Development

10x Genomics is establishing a diagnostics effort to translate our leading singl...

Location

United States , Pleasanton

Salary:

158400.00 - 214400.00 USD / Year

10x Genomics

Expiration Date

Until further notice

Requirements

Ph.D. in Molecular Biology, Genetics, Biochemistry, or a related field, or M.S. with equivalent industry experience
3+ years (Ph.D.), 5+ years (M.S.) of hands-on industry experience in molecular diagnostics or genomics assay development
Extensive, direct hands-on experience with 10x Genomics single-cell and/or spatial technologies, including troubleshooting and optimization
Demonstrated ability to independently adapt and refine published molecular biology protocols
Strong background in NGS workflows, including nucleic acid extraction, PCR/qPCR, and library preparation
Experience working with complex or low-input clinical samples (e.g., FFPE tissue, primary tumor material)
Experience with cell culture methods

Job Responsibility

Assay Development & Execution: Independently execute complex single-cell and spatial genomics workflows
Serve as a hands-on technical expert for 10x Genomics platforms
Systematically troubleshoot and optimize assay workflows
Adapt, refine, and extend published protocols
Design and execute feasibility studies
Process diverse and challenging clinical sample types
Analytical Validation & Documentation: Design and execute experiments supporting analytical validation
Generate, review, and maintain high-quality laboratory documentation
Analyze assay performance metrics and quality control data
Clearly present experimental data and scientific conclusions

What we offer

Equity grants
Comprehensive health and retirement benefit programs
Annual bonus program or sales incentive program
Generous time off
Competitive and comprehensive health benefits package
Family friendly policies like parental leave

Fulltime

Scientist / Senior Scientist, Multimodal AI

Altos Labs is building a world-class AI ecosystem to solve the most complex prob...

Location

United States , San Francisco Bay Area, CA; San Diego, CA

Salary:

188600.00 - 330000.00 USD / Year

Altos Labs

Expiration Date

Until further notice

Requirements

PhD in Computer Science, AI/ML, Biomedical Engineering, or a related quantitative field
Deep experience building and deploying modern Computer Vision architectures (Vision Transformers, U-Nets, Self-Supervised Learning)
Proven experience training and fine-tuning large models at scale using frameworks like PyTorch Distributed, DeepSpeed, or Jax
Expert-level Python skills, with a focus on building production-ready machine learning code and large-scale data management systems
A track record of technical contributions via high-impact publications (CVPR, ICCV, NeurIPS, etc.) or significant contributions to open-source ML frameworks

Job Responsibility

Model Development: Design, code, and train large-scale foundation models (e.g., Vision Transformers, Multimodal LLMs) that can embed spatial data and integrate multiple modalities
Hands-on Data Fusion: Implement innovative cross-domain mapping and fusion strategies to synchronize heterogeneous biological datasets
Scaling & Training: Build and manage high-performance ML pipelines capable of processing petabyte-scale image repositories and multi-omics streams in a cloud environment
Technical Collaboration: Work directly in the trenches with experimental scientists and software engineers to translate biological complexity into performant code and reliable distributed systems

Fulltime

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Process Development Senior Scientist

Job Description

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