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Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Job Responsibility
Work effectively with a diverse team of synthetic chemists, chemical engineers and analytical chemists to invent synthetic routes and develop safe, robust, sustainable and cost-effective processes for antibody drug conjugate, peptide antibody conjugates, synthetic peptides and/or oligonucleotide manufacturing
Drive technology innovation in the synthesis, purification, and characterization of bioconjugates, oligonucleotides, and/or synthetic peptides
Support cGMP manufacturing and technology transfer to our internal manufacturing facilities and external contract manufacturers
Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency
Ensure process performance through process understanding, modeling and characterization
Contribute to drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc
Work cross-functionally to deliver regulatory documents and support regulatory filings
Serve as a technical expert and keep current in the field of bioconjugation, antibody drug conjugate, oligonucleotide, peptide, and process chemistry and manufacturing
Work independently in advancing projects and studies within required deadlines
Requirements
Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
OR Master’s degree and 3 years of Scientific experience
OR Bachelor’s degree and 5 years of Scientific experience
Nice to have
Ph.D. in organic chemistry, chemical biology or biochemistry with expertise in antibody drug conjugate, synthetic oligonucleotide, and/or synthetic peptide process development
Post-doctoral experience in an academic laboratory or pharmaceutical/biotech industry
Extensive hands-on expertise in the synthesis and purification of peptides, oligonucleotides, and/or antibody drug conjugates and experience with bio-conjugation techniques
Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid Chromatography–Mass Spectrometry (LC-MS), Ion-Exchange (IEX), and Reversed Phase (RP)-HPLC
Familiarity with laboratory automation, data analysis and visualization techniques and tools
Track record of peer-reviewed publications and research presentations
Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results
Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects
A research summary included with CV is strongly encouraged
What we offer
Health and welfare plans for staff and eligible dependents
Financial plans with opportunities to save towards retirement or other goals
Work/life balance
Career development opportunities
Retirement and Savings Plan with generous company contributions