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Principal Statistician

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Location:
United Kingdom

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Category:
Research and Development

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Contract Type:
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Salary:

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Job Description:

The Principal Statistician will provide senior-level statistical expertise to support AAVantgarde Bio’s clinical development programs. This role combines hands-on statistical programming, advanced methodological expertise, and independent scientific judgement, working closely with cross-functional teams across Clinical, Medical, Regulatory, Data Management, and Biometrics. A strong focus will be placed on ophthalmology clinical trials and endpoints, ensuring analyses are scientifically rigorous, clinically interpretable, and aligned with regulatory expectations.

Job Responsibility:

  • Provide senior statistical expertise for the design, analysis, and interpretation of clinical trials across clinical development programs
  • Define statistical strategies including estimands, sample size, interim analyses, and analytical approaches
  • Perform hands-on statistical programming and review of analysis datasets, tables, figures, and listings
  • Apply advanced statistical methodologies and ensure alignment with regulatory expectations
  • Support the definition, analysis, and interpretation of ophthalmology-specific clinical endpoints
  • Ensure high-quality, accurate, and inspection-ready statistical deliverables
  • Collaborate closely with Clinical, Medical, Regulatory, Data Management, and Biometrics teams
  • Contribute to statistical sections of protocols, SAPs, clinical study reports, and regulatory documents
  • Act as a statistical thought partner, clearly communicating results and implications to non-statistical stakeholders

Requirements:

  • Senior-level expertise in clinical trial statistics within biotech or pharmaceutical environments
  • Strong hands-on statistical programming experience
  • Deep understanding of advanced statistical methodologies
  • Experience supporting regulatory submissions and inspection-ready deliverables (FDA / EMA)
  • Ability to work independently in a fast-paced, evolving organisation

Nice to have:

  • Prior experience in ophthalmology or rare diseases
  • Experience with external or historical control data
  • Exposure to Bayesian or simulation-based methods
What we offer:
  • Health insurance
  • Psychotherapy coverage
  • Sport coverage
  • Learning budget
  • 18 business days of paid vacation days per year
  • Paid sick leaves
  • All public holidays are paid days off

Additional Information:

Job Posted:
February 18, 2026

Employment Type:
Fulltime
Work Type:
Remote work
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