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AbCellera Biologics Logo AbCellera Biologics · Research and Development

Principal Scientist - Toxicology

Canada, Vancouver Employment contract 134000.00 - 168000.00 CAD / Year · Job Posted June 09, 2026
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Job Description

We are looking for an experienced, strategically minded Principal Scientist to join our expanding Non-Clinical Safety team based in Vancouver, Canada. You will be responsible for designing, planning, monitoring, and reporting of non-GLP and GLP toxicology studies and provide nonclinical safety support for early to late stage programs.

Job Responsibility

  • Leading the planning, design, execution and interpretation of nonclinical toxicology programs in support of IND, CTA and BLA submissions, including general toxicity and reproductive and developmental toxicology studies
  • serving as the primary scientific interface with contract research organizations (CROs)
  • representing the Nonclinical Safety function as a core member of cross-functional discovery and development program teams
  • providing critical scientific assessment of toxicology data and communicating clear, actionable risk-benefit evaluations and recommendations
  • authoring and reviewing nonclinical safety sections of regulatory documents (INDs, CTAs, IBs, and BLAs)
  • driving the development and evolution of integrated nonclinical safety strategies across AbCellera’s therapeutic portfolio
  • maintaining scientific leadership by staying current with advances in toxicology science

Requirements

  • PhD in Toxicology or a related field, with 8+ years of relevant industry experience supporting biologics development
  • MSc degree and 12+ years of directly applicable experience will also be considered
  • deep expertise in GLP-compliant nonclinical toxicology
  • hands-on experience with US FDA 21 CFR Part 58
  • strong working knowledge of FDA, ICH, and EMA nonclinical regulatory guidance
  • proven track record of designing, overseeing, and interpreting non-GLP and GLP toxicology studies in support of discovery and development programs
  • ability to lead scientific discussions and influence decision-making within highly matrixed, cross-functional teams
  • excellent scientific writing skills
  • strong organizational and prioritization skills
  • sound scientific judgment and critical problem-solving skills
  • flexibility, resilience, and a proactive approach to change
  • DABT accreditation (highly desirable, but not required)
  • experience with oncology and/or ADC programs is highly desirable

Nice to have

  • DABT accreditation
  • experience with oncology and/or ADC programs

What we offer

  • Equity
  • annual bonus dependent on team and company performance
  • 6% (non-match) RRSP contribution
  • CAD $1,500 annual Active Lifestyle Allowance
  • annual vacation
  • professional development opportunities
  • comprehensive health benefits
  • scientific and technical mentorship
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