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Amgen Logo Amgen · -

Principal Scientist: PKDM-BA (Small molecule in vitro ADME group lead)

India, Hyderabad · Job Posted June 03, 2026
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Job Responsibility

  • Involve and mentor a team of scientists in the design, execution, and interpretation of in vitro ADME studies
  • Develop, optimize, validate, and implement mechanistic in vitro assays to characterize drug metabolism, transporter interactions, and drug–drug interaction (DDI) risk
  • Design, establish, and validate robust high-throughput screening workflows to support compound profiling and lead optimization efforts
  • Oversee the execution and interpretation of a comprehensive suite of in vitro ADME assays, including: Metabolic stability assessments using liver microsomes, S9 fractions, and hepatocytes
  • Binding assays
  • CYP450 inhibition and induction studies
  • Transporter uptake and efflux assays
  • In vitro drug–drug interaction (DDI) evaluations
  • Manage and maintain cell culture platforms supporting ADME studies, including primary hepatocytes, immortalized cell lines, and transporter-transfected cell systems, ensuring model suitability and reproducibility
  • Supervise permeability and absorption studies using established in vitro models to assess compound absorption potential
  • Ensure data quality, integrity, reproducibility, and timely delivery of results across all in vitro ADME activities, in alignment with internal standards and project timelines
  • Ensure compliance with applicable regulatory guidelines, safety requirements, and internal quality systems, maintaining thorough and audit-ready documentation
  • Develop team members, fostering a culture of scientific rigor, continuous improvement, and innovation

Requirements

  • Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] and directly related experience
  • Master's degree and directly related experience
  • Bachelor's degree and directly related experience

Nice to have

  • PhD in Pharmacokinetics, Pharmaceutical Sciences, or related fields
  • Strong hands-on experience in developing mechanistic in vitro ADME models (e.g. enzyme kinetics, DDI and transporter assays etc) and interpreting complex datasets
  • Proven track record in high-throughput screening and assay automation
  • Team management skills
  • Excellent communication, collaboration, and problem-solving abilities
  • Strong publication or project track record in ADME/DMPK research is a plus
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