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Amgen Logo Amgen · Research and Development

Principal Scientist: PKDM-BA (Small molecule bioanalysis group lead)

India, Hyderabad · Job Posted June 03, 2026
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Job Description

At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together—researching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of.

Job Responsibility

  • Lead and mentor a team of scientists in the design, execution, and interpretation of bioanalytical studies
  • Develop, validate, and implement bioanalytical methods for quantitative measurement of drug candidates, metabolites, and biomarkers in biological matrices
  • Perform and supervise quantitative bioanalysis using LC-MS/MS and other advanced analytical platforms
  • Handle and process complex biological matrices (e.g., plasma, tissue homogenates, urine, bile) with robust extraction procedures to ensure accurate and reproducible results
  • Apply sound knowledge of extraction techniques (e.g., protein precipitation, liquid-liquid extraction, solid-phase extraction) to optimize bioanalytical workflows
  • Ensure compliance with regulatory guidelines and maintain high-quality documentation
  • Collaborate with PKDM project team representatives and BA scientists located at our US sites and ensure integration of bioanalytical data into project decision-making
  • Ensure data quality, integrity, reproducibility, and timely delivery of results while maintaining safety standards across all workflows
  • Mentor and develop team members, promoting a culture of scientific rigor and innovation
  • Contribute to strategic planning and allocation of bioanalytical resources

Requirements

  • Doctorate degree PhD OR PharmD OR MD and relevant post-doc where applicable and xx years of directly related experience
  • Master’s degree and xx years of directly related experience
  • Bachelor’s degree and xx years of directly related experience

Nice to have

  • PhD or Master’s degree in Pharmaceutical Sciences, Analytical Chemistry, or related field
  • Strong hands-on expertise in LC-MS/MS, HPLC, and other bioanalytical techniques for quantitative and qualitative analysis
  • Proven track record in handling complex biological matrices and applying extraction procedures to support bioanalytical method development
  • Experience in bioanalytical method validation and regulatory submissions
  • Demonstrated experience in metabolite identification (Met ID) studies and interpretation of complex datasets
  • Team management skills
  • Excellent communication, collaboration, and problem-solving abilities
  • Strong publication or project track record in ADME/DMPK research is a plus
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