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Principal Scientist, Extracellular Targeted Cancer Therapeutics

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GSK

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Location:
United Kingdom , Stevenage

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Contract Type:
Not provided

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Salary:

Not provided

Job Description:

The Extracellular Targeted Cancer Therapeutics (ETCT) Biology Unit within the Oncology Research Unit is seeking an experienced Principal Scientist/Senior Principal Scientist to contribute to programs in pre-clinical and early clinical phases in the targeted biologics portfolio focusing on antibody-drug conjugates (ADCs) and T cell engagers (TCEs). The candidate will work within multi-disciplinary program teams by contributing to and leading biology strategy, delivering molecule mechanism of action and potency data and providing input into other functions such as pharmacokinetics, non-clinical safety, biomarkers and clinical development. The successful applicant will have prior experience managing cross-functional biologics matrix teams with oversight of critical path biology in the preclinical development of novel biologics for cancer therapy, such as ADCs and TCEs.

Job Responsibility:

  • Design and deliver basic and translational critical path biology work packages as matrix team leader to support pre-clinical and early clinical biologics programs
  • As biology lead, represent the ETCT Biology Unit within programme matrix teams and engage with stakeholders across the organization to deliver the biology strategy
  • Work independently to design and execute impactful experiments which influence the direction of assets in the ETCT BU portfolio. Experiments include potency and mechanism of action studies to deliver decision-driving data for biologics programmes
  • Champion innovative experimental techniques/technologies internally and at CROs
  • Build communication networks across the Research organization
  • Train and mentor junior scientists and complementary workers

Requirements:

  • BSc. or higher degree in Cell Biology, Pharmacology, Immunology or related fields with significant pharmaceutical or biotechnology industry research and leadership experience
  • Deep expertise in cancer biology, good interpersonal skills and an ability to work independently
  • Experience in progressing cancer therapies from target ID to candidate selection and supporting critical path mechanistic biology with simple and complex disease models
  • Experience leading cross-functional drug discovery project teams to develop novel therapeutic platforms for biologics targets
  • Attention to detail and proficient reasoning skills in experimental design, data analysis, statistical methods and interpretation
  • Independence, problem-solving abilities, self-motivation, resourcefulness, and the ability to work in a fast-paced team environment
  • Demonstrated technical expertise in cell culture, general lab instrumentation, cell-based assays such as proliferation, cytotoxicity, immunoassays such as ELISA and experience with Flow Cytometry

Nice to have:

  • MS or PhD in Cell Biology, Pharmacology, Immunology or related fields with demonstrated of post-doctoral training or pharmaceutical/biotechnology industry research and leadership experience
  • Experience with the design and testing of biologics
  • Direct and/or management experience for a range of biologists including biochemists, cellular/molecular biologists and cell-based assay developers and flow cytometry experts
  • Strong peer-reviewed publication, public speaking / presentation and/or inventorship record
What we offer:
  • Competitive base salary
  • Annual bonus based on company performance
  • Flexible working options available for most roles
  • Learning and career development
  • Access to healthcare & wellbeing programmes
  • Employee recognition programmes
  • Competitive salary
  • Annual bonus based on company performance
  • Healthcare and wellbeing programmes
  • Pension plan membership
  • Shares and savings programme
  • Hybrid working model

Additional Information:

Job Posted:
March 18, 2026

Expiration:
March 22, 2026

Employment Type:
Fulltime
Work Type:
Hybrid work
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