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Amgen is seeking a highly motivated Senior Principal Scientist for their Discovery Analytical Chemistry group in their state-of-the-art research and development facility in Genome Valley, India. The Principal Scientist will lead analytical strategy and execution for drug discovery-stage projects, enabling medicinal chemistry and early candidate selection through deep expertise in analytical and separation sciences. This role bridges synthetic and analytical chemistry, ensuring rapid, reliable characterization of novel compounds and intermediates that drive Amgen’s small molecule discovery pipeline.
Job Responsibility:
Lead analytical strategy and execution for drug discovery-stage projects, enabling medicinal chemistry and early candidate selection through deep expertise in analytical and separation sciences
Bridge synthetic and analytical chemistry, ensuring rapid, reliable characterization of novel compounds and intermediates that drive Amgen’s small molecule discovery pipeline
Lead and manage the Synthetic Separations group, providing strategic direction, technical leadership, and mentorship to staff while prioritizing workloads, optimizing team performance, and serving as both a people manager and subject matter expert in synthetic separations
Design and qualify automated workflows enabling rapid turnaround and consistent data quality for purification and analysis of diverse compound libraries
Utilization of a diverse set of instruments and technologies, such as (but not limited to) HPLC, SFC, MS, mass-directed purification, and preparative-scale SFC and LC is necessary
Lead library purification efforts across multiple scales, ranging from microgram-level purification of screening compounds to hundreds of milligrams for advanced characterization
Assist in research efforts directed at improving process efficiencies, expanding the range of assays and applications, building state-of-the-art analytical capabilities, and improving technologies and infrastructure
Requirements:
Ph.D. in Chemistry, Analytical Chemistry, or related field with 8+ years of relevant experience, or M.S. with 12+ years of relevant experience in analytical or discovery chemistry within the biopharmaceutical industry
PhD in Analytical Chemistry or a related discipline with 8+ years of relevant industry experience in chromatographic analysis and/or purification of small molecules within a pharmaceutical R&D environment
Minimum of 5 years in a leadership or people management role
Develop, optimize, and implement analytical methods (LC, LC/MS, GC, SFC, NMR, HRMS, and related techniques) for purity assessment, structural confirmation, quantitative analysis, and reaction monitoring of synthetic compounds
Develop, optimize, and implement analytical methods (LC, LC/MS, GC, SFC, NMR, etc.) for purity assessment, structural confirmation, and reaction monitoring of synthetic compounds
Design, qualify, and maintain high-throughput or automated analytical workflows to support medicinal chemistry cycles
Collaborate with cross-functionally digital and automation groups to enable data-driven analytics and AI-supported structure prediction
Drive continuous improvement in analytical workflows and laboratory efficiency through process automation and robotics
Excellent written and verbal communication skills
Prepare concise, high-quality reports and presentations for internal review and external disclosure
Represent Amgen in scientific collaborations, conferences, and publications related to analytical innovations in drug discovery
Proficiency in managing multiple priorities and driving results in a dynamic research environment
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