Job Description
We are seeking a Principal Machine Learning Engineer to join the Forecasting team within the AI & Data Science organization. As a principal technical leader, this role will set technical direction and design, build, deploy, and scale enterprise-grade machine learning, large language model, and agentic AI systems that power forecasting capabilities, uncertainty-aware decision support, scenario planning, and operational decision automation across Amgen. This role blends deep machine learning engineering expertise, modern AI systems architecture, and product-minded delivery. The Principal Machine Learning Engineer will solve highly ambiguous problems, identify high-impact automation opportunities, and translate advanced forecasting, predictive analytics, LLM-powered applications, and AI agent patterns into reliable, governed production solutions that support critical business processes and help Amgen deliver on its "every patient, every time" mandate. The role is well suited to a hands-on technical leader who has shipped mission-critical AI/ML systems to production, understands the practical challenges of MLOps, and can operate effectively across engineering, data science, product, operations, commercial, manufacturing, supply chain, and senior stakeholder groups.
