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Principal Downstream Scientist – mRNA purification

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GSK

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Location:
United States , Cambridge

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Category:
Research and Development

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Contract Type:
Not provided

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Salary:

115500.00 - 192500.00 USD / Year
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Job Description:

Are you ready to make a meaningful impact in the development of mRNA-based vaccines? As a Principal Downstream Scientist specializing in mRNA purification, you will play a key role in advancing innovative vaccine platforms. You will design and optimize purification processes, collaborate with cross-functional teams, and contribute to the development of scalable solutions. We value candidates who are driven, collaborative, and eager to bring fresh ideas to the table. This role is based in the United States and offers an exciting opportunity to work at the forefront of vaccine development.

Job Responsibility:

  • Design, execute, and analyze experiments to develop and optimize mRNA purification processes
  • Ensure processes are scalable and phase-appropriate for clinical manufacturing
  • Collaborate with global teams, including analytical R&D, GMP, and process development colleagues
  • Drive innovative solutions to improve purification techniques and meet project milestones
  • Stay current with industry trends and emerging technologies in downstream processing
  • Maintain detailed documentation to ensure data integrity and compliance

Requirements:

  • Master’s or PhD. degree in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field
  • Five years (Master's) or Three years (PhD.) of industry experience in downstream process development for large biomolecules, including mRNA or pDNA
  • Three or more years of experience with purification techniques such as affinity capture, ion exchange, and hydrophobic interactions
  • Three or more years of experience supporting CMC activities, including process and analytical development

Nice to have:

  • PhD in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering, or a related field
  • Experience with Quality by Design principles and DOE studies for process optimization
  • Knowledge of regulatory guidelines (FDA/ICH/ISPE) for process validation and technology transfer
  • Familiarity with nucleic acid analytical technologies
  • Strong problem-solving skills and ability to work collaboratively in a matrixed environment
What we offer:
  • Competitive base salary
  • Annual bonus based on company performance
  • Flexible working options available for most roles
  • Learning and career development
  • Access to healthcare & wellbeing programmes
  • Employee recognition programmes
  • Eligibility to participate in our share based long term incentive program
  • Health care and other insurance benefits (for employee and family)
  • Retirement benefits
  • Paid holidays
  • Vacation
  • Paid caregiver/parental and medical leave

Additional Information:

Job Posted:
March 21, 2026

Employment Type:
Fulltime
Work Type:
On-site work
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