Principal Computational Chemist

Join our Computational Drug Design Team to play a key role in the development and application of Orbis Medicines’ next-generation nCycle platform. Orbis Medicines is a pioneering Biotech company powered by our automated nGen chemistry platform and data-driven approach. We develop oral alternatives to injectable biologics and design drugs for hard-to-drug targets primarily in inflammation and immune-driven diseases. Orbis’ nGen platform designs macrocycles with oral bioavailability (nCycles) by combining AI technologies with automated synthesis and high-throughput screening of real compounds. We are seeking a Principal Computational Chemist to lead our efforts to uncover new nCycles for difficult-to-drug targets and shape our structure-based design strategy for macrocyclic peptide programs. This is a senior scientific leadership role with direct impact on the development of our macrocyclic peptide platform.