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A cancer research laboratory under Dr. Jezabel Rodriguez-Blanco within the Hollings Cancer Center and the Darby Children’s Research Institute has an opening for a postdoctoral position. This lab utilizes in vitro, ex vivo, and in vivo models, including genetic mouse models and patient-derived orthotopic xenografts, to investigate the intracellular drivers of pediatric brain tumor growth. The primary research focus is on elucidating the signaling mechanisms that contribute to the relapse of medulloblastoma, the most common malignant pediatric brain tumor.
Job Responsibility:
Experimental Design and Execution: Work collaboratively to design and execute experiments using advanced mouse genetic models and cell-based studies to identify drivers of medulloblastoma growth and relapse
Data Collection and Analysis: Support data collection and analysis from experiments, maintaining accurate records, utilizing software, collaborating with shared resources, interpreting results, and planning new experiments
Manuscript and Grant Preparation: Contribute to manuscript and grant preparation based on experimental findings, keeping current with literature, preparing data figures, drafting manuscripts and grants, presenting research
Laboratory Maintenance and Compliance: Assist with laboratory upkeep and regulatory compliance, including ordering supplies, maintaining reagents, ensuring equipment functionality, preparing IACUC protocols
Requirements:
Recent Ph.D. in cancer biology, neurosciences, or a related field
Strong background in molecular and cell biology, and biochemistry
Experience with mouse genetic models and survival surgeries, including brain tumor implants (preferred)
Familiarity with CRISPR screening and bioinformatics analyses (advantage)
Must have previous experience in a laboratory
Strong organizational, record-keeping, interpersonal, and communication skills
Ability to perform complex calculations, follow detailed experimental procedures and protocols
Experience in animal husbandry, mouse surgeries, and colony management (preferred)
Prior experience in PCR, recombinant DNA techniques, RNA, and protein analysis is required
Availability to work occasionally on weekends, holidays, or evenings may be necessary
Ability to obtain and maintain a valid driver's license
Computer literacy
Ability to work rotating shifts as required
Ability to work overtime as required
Ability to learn and use new processes, tools and equipment as required
Nice to have:
Experience with mouse genetic models and survival surgeries, including brain tumor implants
Familiarity with CRISPR screening and bioinformatics analyses
Experience in animal husbandry, mouse surgeries, and colony management