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Location:
Denmark, Copenhagen

Category:
Research and Development

Contract Type:
Not provided

Salary:

Not provided

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Job Description:

The Sandelin group and collaborators are seeking a talented and motivated postdoctoral researcher to join an interdisciplinary project exploring how maternal immune activation affects fetal development through immune and metabolic pathways. The position is part of a collaboration between the Sandelin group (University of Copenhagen), the Hougaard group (National Research Centre for the Working Environment, NFA) and the Krautz group (University of Copenhagen). The position is for two years with possible extension. Our overarching goal is to dissect how maternal IL-6 signalling and SOCS3-mediated immune inhibition in the placenta determine whether the fetus responds to maternal inflammation by immune activation and/or metabolic rewiring. This research builds on our recent multi-omics study (Nature Communications, 2024) demonstrating that maternal lung inflammation at low levels leads to fetal metabolic adaptation without direct immune activation. The project integrates molecular physiology, multi-omics, and spatial systems biology to uncover the mechanistic basis of this immune-metabolic switch. The successful candidate will join a vibrant group of interdisciplinary scientists in eg bioinformatics, cell biology, physiology and genomics.

Job Responsibility:

Lead experimental and/or computational work to: Map dose-dependent IL-6 responses in the maternal-placental-fetal axis using transcriptomics, lipidomics, and metabolomics
Determine thresholds where placental immune inhibition fails and triggers fetal immune activation
Identify cell types and microanatomical regions responsible for immune inhibition in the placenta and metabolic rewiring in the fetal liver
Integrate single-cell spatial transcriptomics and spatial lipidomics to create quantitative models of immune-metabolic communication across tissues
Conduct independent and collaborative research within the project’s scope
May also contribute to teaching and supervision within the department

Requirements:

PhD in molecular biology, bioinformatics, or a related field
Strong background in one or more of the following areas: Molecular biology, especially genomics methods
Spatial omics, including spatial transcriptomics
Bioinformatics, especially integration of multi-omics datasets and spatial data
Excellent written and spoken English, with proven ability in scientific communication and collaboration
Strong motivation to work in an interdisciplinary and collaborative environment
One or more first-author publications in high-quality journals in genomics, systems biology, data-driven bioinformatics, or physiology

What we offer:

Negotiation for salary supplement is possible

Additional Information:

Job Posted:
December 09, 2025

Expiration:
January 14, 2026

Employment Type:

Fulltime

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Postdoctoral researcher

jobRxiv

Location:Denmark, Copenhagen

Category:Research and Development

Contract Type:Not provided