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Postdoctoral Researcher in Dynamic Control of Ciliary Transport

Czech Republic, Vestec, Prague-west Employment contract · Job Posted February 01, 2026
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Job Description

The postdoc will establish and optimize the auxin-induced degradation (AID) system in C. elegans to enable precise temporal control over ciliary protein activity. This dynamic manipulation will be used to probe the functional roles of intraflagellar transport (IFT) components and ciliary membrane proteins, linking their single-molecule dynamics to changes in ciliary architecture and function. The successful candidate will work at the interface of molecular biology, quantitative imaging, and biophysics, developing transgenic worm strains, integrating AID with advanced fluorescence microscopy and collaborating with theoretical biophysicists to model IFT dynamics.

Job Responsibility

  • Develop and optimize the AID2 system in C. elegans to control ciliary protein levels with spatial and temporal precision
  • Design and generate transgenic worm strains using CRISPR/Cas9 and MosSCI
  • Use advanced fluorescence microscopy to quantitatively image ciliary protein dynamics in living C. elegans while inducing rapid changes in protein function
  • Collaborate with team members and theoretician collaborators to link experimental results with quantitative modelling of IFT
  • Contribute to manuscript preparation, grant reporting, and supervision of students in the lab
  • Present research findings at national and international conferences

Requirements

  • PhD in molecular or cell biology, genetics, biophysics, or a related field (completed or near completion)
  • Experience in C. elegans genetics and transgenesis, with molecular cloning expertise desired
  • Hands-on experience in fluorescence microscopy and quantitative image analysis
  • Excellent written and spoken English, and good communication skills for collaborative work
  • Curious, inventive, and hands-on scientist who enjoys bridging molecular biology, imaging, and image analysis
  • Independent yet collaborative
  • Strong sense of initiative, precision, and perseverance in experimental work
  • Open and constructive mindset

What we offer

  • Stimulating, international, and interdisciplinary environment within BIOCEV Center, a research center hosting over 50 research groups and state-of-the-art core facilities
  • Involvement in top-level scientific research infrastructure
  • Competitive salary commensurate with experience and Czech Academy of Sciences standards
  • 5 weeks of vacation
  • Meal allowance
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