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Portfolio / Program Manager - Operational Readiness

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GSK

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Location:
United States , Marietta

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Category:

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Contract Type:
Not provided

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Salary:

Not provided

Job Description:

GSK is embarking on the development of a state-of-the-art manufacturing facility, representing an $800M+ investment in advancing pharmaceutical innovation. This project offers an exciting opportunity to be part of a transformative initiative that will shape the future of manufacturing and operational excellence. The Portfolio & Program Manager – Operational Readiness is accountable for end-to-end operational readiness planning and execution for a new facility introduction. The role integrates cross-functional workstreams into a single executable readiness plan, drives schedule acceleration opportunities, ensures governance discipline, and enables “operational excellence from day one” through GPS and digital foundations. The role operates in parallel with construction/commissioning activities to ensure the site is ready to accept handover and achieve successful PPQ / facility approval readiness through robust SOPs, training, tech transfer alignment, incoming materials readiness, procurement execution, and risk controls.

Job Responsibility:

  • Build, maintain, and govern the integrated operational readiness schedule across workstreams (SOPs, Tech Transfer, GPS, Incoming Materials, Procurement) aligned to the Integrated Master Schedule and critical path.
  • Drive schedule convergence and acceleration: identify dependencies, sequencing conflicts, resourcing gaps, and pull-forward actions
  • run weekly lookahead planning and escalation for overdue/at-risk deliverables.
  • Establish readiness stage-gates and define entry/exit criteria with stakeholders to confirm readiness at critical milestones.
  • Coordinate prioritization, drafting, field shakedown, review, and approval of SOPs to enable shopfloor readiness.
  • Ensure clear document strategy and ownership (e.g., what lives in SOP vs eBR vs local instructions) and maintain a document tracker integrated into the master schedule.
  • Oversee the tracking and management of closure for safety, HAZOP, and risk assessment open items, ensuring all actions are completed in a timely manner.
  • Coordinate effectively across teams to guarantee proper resolution and communication of outstanding safety and risk-related tasks.
  • Ensure operational readiness deliverables and timing remain aligned to Tech Transfer plans, donor site inputs, and QC method transfer planning.
  • Integrate key Tech Transfer and QC readiness milestones into site reporting and governance.
  • Oversee change control processes to ensure they are fully aligned with regulatory requirements, optimized for efficiency, and consistently executed according to established schedules.
  • Continuously evaluate and refine change management practices, promoting accountability and timely decision-making to support project objectives and operational excellence.
  • Drive operational excellence foundations: tier governance cadence, GEMBA/self-inspection routines, and readiness operating model embedded from the start.
  • Enable stable execution through standard work, performance management, and continuous improvement rituals.
  • Coordinate supplier transparency setup, material master data readiness, BOM redlines, and incoming materials strategy/list development.
  • Ensure materials readiness is linked to eBR/MES needs, procurement lead times, and commissioning/start-up sequencing.
  • Track procurement readiness for key packages and readiness blockers
  • coordinate mitigations where procurement timing threatens critical path.
  • Partner with Engineering/Project teams to ensure procurement deliverables support FAT/SAT, start-up, and operational readiness needs.
  • Ensure the integration of smart manufacturing technologies and digital solutions across operational readiness workstreams to enhance process visibility, data-driven decision-making, and automation.
  • Collaborate with IT, engineering, and operations to deploy advanced manufacturing systems such as IoT sensors, real-time analytics platforms, and digital twins, ensuring alignment with the operational readiness schedule and critical milestones.
  • Own the operational readiness risk & issue management rhythm: identification, assessment, mitigation planning, and escalation.
  • Maintain and govern the project risk register
  • ensure mitigations have owners, due dates, and are integrated into the readiness schedule.
  • Facilitate recurring risk reviews and ensure lessons learned feed back into schedule, training, and readiness deliverables.
  • Build and maintain readiness dashboards (tier boards/scorecards) for Safety, Quality, Supply, and schedule conformance
  • drive consistent weekly reporting.
  • Define and implement KPI reporting discipline for monthly leadership updates
  • ensure data integrity and clear action linkage.
  • Track readiness KPIs such as Right-First-Time execution, conformance to schedule, and critical path adherence
  • drive countermeasures through tier governance.
  • Ensure operations is embedded with the project team and prepared for handover through early training exposure and readiness deliverables tied to system lifecycle activities.
  • Promote a strong ownership and learning culture
  • leverage best practices and lessons learned from sister sites or prior launches where applicable

Requirements:

  • BS/BA in Engineering, Life Sciences, Operations, Supply Chain, or related field (MS/MBA helpful for seniority)
  • 4+ Years of experience in project, portfolio or program management.
  • Program/Project credential (PMP, PgMP, or equivalent)
  • Change management certification (Prosci) can be a plus if org design/training adoption is heavy
  • Demonstrated program/portfolio management experience (integrated schedules, dependencies, critical path, governance cadence).
  • Experience leading cross-functional readiness, launch, or operationalization programs in regulated manufacturing environments.
  • Strong risk/issue management discipline (risk registers, mitigation ownership, escalation).
  • Executive-ready communication skills: concise dashboards, narrative updates, and decision framing.
  • New facility introduction / expansion experience
  • operational readiness executed in parallel with construction/commissioning.
  • Familiarity with tier-based management systems and shopfloor GPS cadence.
  • Lean / Six Sigma experience, especially if the role is expected to embed GPS/continuous improvement
  • Exposure to digital manufacturing foundations (e.g., MES/eBR readiness coordination).

Nice to have:

  • Program/Project credential (PMP, PgMP, or equivalent)
  • Change management certification (Prosci) can be a plus if org design/training adoption is heavy
  • Demonstrated program/portfolio management experience (integrated schedules, dependencies, critical path, governance cadence).
  • Experience leading cross-functional readiness, launch, or operationalization programs in regulated manufacturing environments.
  • Strong risk/issue management discipline (risk registers, mitigation ownership, escalation).
  • Executive-ready communication skills: concise dashboards, narrative updates, and decision framing.
  • New facility introduction / expansion experience
  • operational readiness executed in parallel with construction/commissioning.
  • Familiarity with tier-based management systems and shopfloor GPS cadence.
  • Lean / Six Sigma experience, especially if the role is expected to embed GPS/continuous improvement
  • Exposure to digital manufacturing foundations (e.g., MES/eBR readiness coordination).
What we offer:
  • Competitive base salary
  • Annual bonus based on company performance
  • Flexible working options available for most roles
  • Learning and career development
  • Access to healthcare & wellbeing programmes
  • Employee recognition programmes

Additional Information:

Job Posted:
March 18, 2026

Employment Type:
Fulltime
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