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The PhD project will investigate how sympathetic ganglia sense disease and reprogram themselves, initiating waves of inflammation and tissue remodeling in the heart. Specifically, you will use advanced molecular profiling (single-nucleus transcriptomics, proteomics), imaging, and functional assays in mouse models to identify key molecular nodes linking sympathetic overactivation, immune cell infiltration, and cardiac fibrosis.
Job Responsibility:
Design and execute experiments investigating sympathetic remodeling mechanisms in (in vivo, in vitro and ex vivo) disease models
Apply cutting-edge omics and imaging techniques to characterize cellular and molecular changes
Analyze complex datasets and generate biological insights
Contribute to group seminars, manuscript preparation, and lab discussions
Requirements:
Successfully completed scientific university studies (Master’s degree) in a relevant field such as biology, biochemistry or a related discipline with a strong focus on molecular biology, cell biology or biochemistry is preferred
Demonstrated research independence and scientific curiosity
Fluent English (written and oral)
Previous experience working with mice or rats is an advantage but not required
Nice to have:
Previous experience working with mice or rats
What we offer:
An opportunity to work in an international team
Our researchers have the opportunity to work on various model systems by making use of the latest cutting-edge technologies
Researchers are supported by state-of-the-art core facilities which offer services in next-generation sequencing, proteomics, bioinformatics, cytometry, microscopy, and small animal imaging