Phd student in parp-1 dynamics and dna repair mechanisms

An exciting opportunity has arisen for a motivated Ph.D. student to join a dynamic research team at the CHU de Québec-Université Laval Research Center. This studentship, funded by the Canadian Institutes of Health Research (CIHR), is available starting April 1, 2026. The successful candidate will be enrolled in a doctoral program at Laval University. The core of this Ph.D. project will be to investigate the intricate relationship between PARP-1 (Poly(ADP-ribose) polymerase-1), its product Poly(ADP-ribose), and the cellular mechanisms of double-strand break repair. PARP1 represents the predominant therapeutic target in DNA damage response (DDR)-focused oncology, functioning as a critical molecular "first-responder" that orchestrates multiple DNA repair pathways. This fundamental research has direct translational implications for the development and optimization of cancer therapies, particularly for cancers exhibiting deficiencies in homologous recombination. The student will be immersed in a cutting-edge research environment and will contribute to a project with significant potential to impact patient care.