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ABG - Association Bernard Gregory Logo ABG - Association Bernard Gregory · Research and Development

PhD project: Understanding the genetic causes of amyotrophic lateral sclerosis

Czech Republic, Prague · Job Posted February 13, 2026
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Job Description

This PhD project aims to uncover novel genetic contributors to ALS using whole genome sequencing (WGS). You will work with a unique biobank of 250 well-characterized ALS patients established in the Slachtova Lab and integrate genomic data with detailed clinical information. Your work will help reveal disease mechanisms and contribute to future precision medicine approaches for patients with ALS.

Job Responsibility

  • Analyse whole genome sequencing data from ALS patients
  • Identify known and novel genetic variants linked to ALS and explore genotype–phenotype relationships using clinical data
  • Work with large-scale genomic datasets using bioinformatics tools, collaborate with neurologists, geneticists, and other experts

Requirements

  • Master students
  • Doctoral candidate
  • PhD-holder
  • Curious, self-motivated person who enjoys learning new things
  • Likes working with large datasets, solving complex problems, and collaborating with others
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