PhD positions in quantitative imaging of ciliary transport

• Track A — Single-Molecule Dissection of Ciliary Entry: Use single-molecule imaging in living neurons to track proteins from dendritic transport to ciliary entry and quantify their interactions with the IFT machinery
• Work with state-of-the-art microscopy, genetically encoded reporters, and quantitative image analysis to study molecular dynamics in vivo
• Track B — Developing Next-Generation Imaging with Synthetic Dyes: Build new imaging technology
• Develop methods that combine ensemble (bulk) and single-molecule measurements in the same living cell, using self-labelling tags (HaloTag/SNAP-tag) and bright synthetic fluorophores
• Establish strategies to track individual molecules over long times with superior brightness and photostability
• Image the same protein population simultaneously at single-molecule and ensemble levels
• Visualize transport, entry, exit, and recycling of proteins in sensory cilia in real time

• Master’s degree in molecular/cellular biology, biophysics, physics, bioengineering, chemistry, or a related field
• Interest in microscopy and quantitative approaches
• Prior experience with C. elegans, imaging, optics, or coding is welcome but not required

Prior experience with C. elegans, imaging, optics, or coding

• Fully funded PhD positions (or co-funded according to admission outcome)
• Training in advanced live-cell and single-molecule microscopy
• An international, interdisciplinary environment at the BIOCEV research center
• Access to state-of-the-art imaging facilities (TIRF, spinning-disk, lattice light-sheet)
• Supportive mentoring in a newly built, creative research group where you can shape your project