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We are seeking a highly motivated PhD student to join an interdisciplinary research project focused on Midichloria, a unique intracellular symbiont capable of invading mitochondria of oocytes of several tick species, e.g. Ixodes ricinus. Despite its exceptional biology, the mechanisms underlying mitochondrial specificity of Midichloria remain unknown. This project aims to identify metabolic and functional features that render mitochondria susceptible to bacterial invasion, addressing a fundamental question in host–symbiont interactions. Overall, this research will reveal general principles of mitochondrial recognition by intracellular bacteria and provide a conceptual framework for exploiting symbiotic interactions to modulate mitochondrial states.
Job Responsibility:
Investigate whether mitochondrial invasion is associated with distinct mitochondrial states reflecting altered metabolic activity or functional imbalance
Examine mitochondrial physiology, stress-related and redox-associated processes in relation to symbiont localization, integrating imaging-based approaches with targeted molecular and biochemical analyses
Explore whether Midichloria can retain its mitochondrial targeting capacity beyond its native host environment, testing the robustness and specificity of this interaction across biological systems
Requirements:
Master’s degree in biology or a related life science field (completed before the start of the PhD)
Experience with cell biology, microbiology, or molecular biology approaches
Basic familiarity with microscopy, biochemical, or molecular techniques
Good communication skills in English (written and spoken)
Ability to work independently as well as collaboratively in an interdisciplinary research environment
Strong interest in experimental research and fundamental biological questions
What we offer:
5 weeks of paid holiday yearly
Subsidized lunches in our own canteen
Pension insurance contribution
Support of leisure sport & cultural activities
Full health insurance and social security
Student benefits for PhD students
Free Czech language classes
Professional trainings and mentoring programme
Concessionary services at the contractual operator and bank
Campus-based daycare for employees’ children from the age of 1 year
Welcome service and further support for foreigners (HR Award)
English speaking, friendly & stimulating international working environment
Work-life balance in a middle-sized university city offering options for various activities
Working in a stable, prestigious research institution of international importance