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Cell-targeted Biophotonic Nanoparticles for Vision Restoration. The project aims to functionalize NPs with recombinant antibodies or AI-driven binding peptides targeting mGluR6, a unique marker of ON-bipolar cells, to allow targeting the ON-pathway in gene-free fashion and restoring the ON/OFF-signature of retinal processing responsible for spatial resolution and contrast sensitivity.
Job Responsibility:
Functionalize NPs with recombinant antibodies or AI-driven binding peptides targeting mGluR6 to make photostimulation cell-specific
Target the ON-pathway in gene-free fashion to restore the ON/OFF-signature of retinal processing responsible for spatial resolution and contrast sensitivity
Requirements:
Masters-level degree (4/5-year undergraduate MSc/MChem/MEng or postgraduate Masters)
Grade corresponding to an upper second class (2.1) or merit in UK system or 100/110 in Italian system
Valid IELTS certificate with overall score of 6.5 (no less than 6.0 in any category) if English is not first language
Previous experience in in vivo studies in experimental models of retinal degeneration
Experience in retina and visual cortex electrophysiology
Experience in study of light-driven behaviors
Experience in immunohistochemistry of the retina
Nice to have:
Documented experience in animal experimentation
Documented experience in morphological techniques
Experience in molecular and cellular biology, ex vivo electrophysiology, and in vivo functional studies