Peptide Drug Design Scientist

• Drive the design and optimization of second-generation peptide agonists targeting a Class B GPCR
• Lead SAR and molecular engineering efforts to improve potency, efficacy, selectivity, stability, absorption, PK/PD, and half-life
• Design differentiated analogs guided by strong scientific rationale and experimental insight
• Work closely with internal biology, pharmacology, and formulation teams that have established a broad set of translational and mechanistic assays to support rapid design-test-learn cycles
• Integrate pharmacology, formulation, and DMPK insights to guide iterative optimization
• Collaborate with CROs and multidisciplinary external partners across discovery and development activities
• Generate and evaluate novel scientific hypotheses with a rigorous and data-driven mindset
• Work closely with our CSO and VP of IP and contribute to IP generation

• PhD in peptide chemistry, medicinal chemistry, or related discipline
• Strong track record in peptide therapeutic discovery, ideally including GPCR agonist programs
• Deep expertise in peptide engineering, long-acting peptide modalities and receptor pharmacology
• Highly self-driven scientist with strong ownership mentality and high scientific standards
• Motivated by science-first innovation and hands-on problem solving rather than organizational complexity or corporate strategy
• Creative, rigorous, and structured in experimental thinking and execution
• Comfortable operating independently in a small, fast-moving, and highly collaborative biotech environment
• Excellent project management skills

Experience with intellectual property strategy and/or peptide CMC and developability considerations

• Opportunity to shape the next generation of peptide therapeutics around a promising cardiovascular target
• High degree of scientific ownership and influence on future clinical candidates
• Small, highly capable, and execution-focused team with rapid learning cycles and decision-making
• Access to established biology, pharmacology, and formulation capabilities enabling rapid scientific iteration
• Ability to work at the forefront of peptide science with direct translational impact
• Opportunity to help build a differentiated peptide franchise beyond the first clinical asset