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Modelling Director

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Life Science Talent

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Location:
Denmark , Søborg

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Contract Type:
Not provided

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Salary:

Not provided

Job Description:

Zealand Pharma is expanding its Modelling & Simulation capabilities and is seeking a Director-level, hands-on Translational PK/PD modeller to drive MIDD across preclinical and early clinical programs. The position focuses on developing and applying empirical, semi-mechanistic, and mechanistic PK/PD models to inform lead candidate selection, biomarker strategy, and early clinical dose selection.

Job Responsibility:

  • Lead and execute hands-on mechanistic and translational PK/PD modelling and simulation to enable MIDD from preclinical through early clinical development
  • Develop and apply mechanistic and semi-mechanistic models (e.g., TMDD, PBPK, systems PK/PD, and disease models) to support dose selection, study design, and development strategy
  • Translate preclinical PK/PD and biomarker data into quantitative predictions for first-in-human and early clinical studies, supporting go/no-go and design decisions
  • Drive and manage collaborations with external partners (including CROs), ensuring high scientific quality and timely delivery of modelling outputs
  • Contribute to internal governance, external collaborations, and MIDD-relevant documentation, supporting regulatory strategy where needed

Requirements:

  • PhD in pharmacometrics, PK/PD modelling, PBPK, quantitative systems pharmacology, or a related quantitative discipline, with extensive relevant industry experience
  • Strong track record in translational and mechanistic PK/PD modelling impacting early clinical development decisions
  • Extensive hands-on experience with MATLAB/SimBiology, PBPK software, or similar tools for mechanistic modelling
  • Experience with R and population PK/PD tools (e.g., NONMEM, Phoenix) and applying population approaches alongside mechanistic models
  • Solid understanding of MIDD concepts, including quantitative translation, biomarker integration, and model-based dose selection and study design
  • Experience writing and/or contributing to regulatory documents/submissions
  • ability to communicate assumptions, limitations, and impact clearly to senior stakeholders

Additional Information:

Job Posted:
March 26, 2026

Expiration:
April 06, 2026

Employment Type:
Fulltime
Work Type:
On-site work
Job Link Share:

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