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Master Thesis – Advancing Bispecific Antibody Purification

Sweden, Uppsala · Job Posted June 01, 2026
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Job Description

At Cytiva, we are continuously innovating chromatography solutions to meet the evolving needs of biopharmaceutical manufacturing. Bispecific antibodies (bsAbs) represent a promising class of next-generation therapeutics, but their complex structure introduces unique challenges in downstream processing. In particular, the capture step must efficiently remove product-related impurities such as half-antibodies and homodimers. Recent advancements in tailor-made affinity resins have shown improved purification outcomes compared to traditional resins. This thesis project will explore the performance of modern affinity resins in bsAb capture and assess their impact on overall process efficiency and sustainability.

Job Responsibility

  • You will conduct lab-based experiments to: Alkaline stability studie of affinity resins in bsAb capture
  • Analyze samples using techniques such as HPLC-SEC/RPC, MALS, electrophoresis, and fluorometric assays

Requirements

  • Master’s student in Science or Engineering with a focus on chemistry, biochemistry, or biotechnology
  • Eligible for master thesis work between January 2026 – June 2026
  • Background in chromatography is advantageous
  • Independent, structured, and curious about biotherapeutic development

Nice to have

Background in chromatography

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