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Laboratory Director/Senior Laboratory Director - Oncology

BillionToOne

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Location:
United States , Menlo Park

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Category:
IT - Administration

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Contract Type:
Not provided

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Salary:

216481.00 - 264002.00 USD / Year
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Job Description:

We are seeking an experienced and highly skilled Molecular Genetics Clinical Laboratory Director – Oncology or Senior Laboratory Director – Oncology to provide technical leadership and oversee the daily operations of our high-complexity oncology clinical laboratory. The Oncology Laboratory Director is responsible for ensuring accurate interpretation and reporting of oncology test results, maintaining regulatory compliance, driving quality improvements, and collaborating cross-functionally to advance our oncology assays.

Job Responsibility:

  • Provide technical oversight to ensure high-quality oncology testing and alignment with laboratory and clinical goals
  • Interpret somatic variant results from Northstar liquid biopsy assays, classify variants, and sign out oncology clinical reports
  • Troubleshoot technical issues related to oncology workflows, including liquid biopsy sample prep, NGS library preparation, sequencing, and data analysis
  • Evaluate lab performance, implement process improvements, and promote robust quality assurance systems
  • Review Non-Conforming Events and CAPAs to ensure timely resolution of issues impacting oncology test performance
  • Ensure compliance with CLIA, CAP, NYSDOH, and other applicable regulatory standards for oncology assays
  • Oversee accurate documentation of SOPs, validation reports, QC records, personnel competencies, proficiency testing, and report archives
  • Collaborate with bioinformatics, R&D, and medical affairs on assay development, interpretation guidelines, and continuous assay optimization
  • Participate in budget planning and manage lab expenses to ensure financial efficiency while maintaining exceptional quality
  • Support special projects, including scaling new oncology tests, preparing for inspections, and implementing automation
  • Serve as a subject matter expert on oncology variant interpretation, including AMP/CAP/NYS guidelines

Requirements:

  • Doctoral degree (PhD, MD, or equivalent) in genetics, molecular biology, or a related field
  • Board certification (ABMGG, ABP in Molecular Genetic Pathology, or equivalent)
  • Valid or eligible for California Clinical Laboratory Director license (CGMB, CGMBS, MD/DO licensure) and New York State CoQ in oncology testing
  • 4+ years in a regulated clinical laboratory environment (CLIA/CAP/NYSDOH), with at least 3 years in molecular oncology testing including NGS
  • Proven leadership in developing, validating, and implementing oncology assays (e.g., somatic mutation panels, methylation assays)
  • Deep knowledge of cancer genomics, including tumor heterogeneity, somatic driver mutations, and targeted therapies
  • Experience with variant interpretation databases (COSMIC, OncoKB, ClinVar), IGV, BAM file review, and molecular tumor board participation
  • Strong analytical, communication, and organizational skills, with a track record of leading teams in high-growth environments
  • Proficiency with LIMS and oncology-focused bioinformatics tools
What we offer:
  • Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
  • Open, transparent culture that includes weekly Town Hall meetings
  • The ability to indirectly or directly change the lives of hundreds of thousands patients
  • Multiple medical benefit options
  • employee premiums paid 100% of select plans, dependents covered up to 80%
  • Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
  • Supplemental fertility benefits coverage
  • Retirement savings program including a 4% Company match
  • Increase paid time off with increased tenure
  • Latest and greatest hardware (laptop, lab equipment, facilities)
  • Free daily on-site lunches provided from top eateries
  • A variety of perks on campus (state of the art gym, restaurant)
  • Free on-site EV charging (compatible with all EVs, including Tesla)
  • Generous equity options offering
  • Corporate bonus program

Additional Information:

Job Posted:
December 26, 2025

Employment Type:
Fulltime
Work Type:
On-site work
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