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The Director of Medicinal Chemistry will spearhead the small-molecule R&D strategy in Shanghai, leading a high-performing team to advance projects from hit identification through PCC selection to IND submission. This role requires a blend of deep scientific expertise and strategic leadership within a fast-paced, innovation-driven environment.
Job Responsibility:
Formulate and execute R&D strategies
Make critical decisions on project direction, resource allocation, and risk management
Lead SAR optimization and molecular design based on structural biology and computational chemistry
Apply cutting-edge modalities such as PROTACs, covalent inhibitors, and AI-assisted drug design
Partner with Biology, DMPK, and Toxicology teams to balance physico-chemical properties and ADMET profiles
Recruit, mentor, and motivate a team of chemists, ensuring the highest standards of scientific rigor and data quality
Requirements:
Ph.D. in Organic or Medicinal Chemistry
Minimum 8 years of experience in small-molecule drug discovery within Multinational Corporations (MNCs) or top-tier industry leaders
Direct experience advancing at least one project to PCC
Proven track record of successful IND submissions
Prior experience managing a medicinal chemistry team of at least 5+ members