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Head of Bioreactor Scale-Up, Upstream Modeling

· Job Posted May 03, 2026
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Job Description

A global biologics manufacturing organization is seeking a Head of Bioreactor Scale-Up, Upstream Modeling to lead a specialized team responsible for process scale-up modeling within the upstream process development function. This role combines deep technical ownership with people leadership and is suited to an individual who wants to remain hands-on in science while guiding a small expert team. The Head of will be responsible for defining and driving scale-up strategies for mammalian and microbial processes, ensuring robust transfer from development scale to large-scale manufacturing. The position will also own the continued development of a proprietary scale-up model and help shape the future direction of modeling tools and methodologies. This is a highly technical leadership opportunity for someone with strong expertise in bioreactor scale-up, engineering principles, and process modeling, combined with the ability to communicate clearly with internal stakeholders and external customers.

Job Responsibility

  • Lead and provide technical direction to a specialized team focused on upstream process scale-up modeling
  • Define and execute the strategy for the company’s proprietary scale-up model
  • Drive the continued development and modernization of the modeling platform, including transition from Excel/VBA to Python
  • Act as the key decision-maker for the modeling team and unify technical approaches across projects
  • Serve as a subject matter expert on customer programs involving process transfer and scale-up
  • Support successful scale-up from small-scale development systems to large-scale bioreactors up to 20,000L
  • Provide expertise in bioreactor characterization, mixing strategies, gassing strategies, and engineering fundamentals relevant to process scale-up
  • Interface directly with customers and present, explain, and defend modeling strategies and conclusions
  • Collaborate with internal technical teams to support robust process development and transfer
  • Supervise, coach, and develop team members
  • Help create technical alignment within an international team with different scientific perspectives
  • Contribute to the future expansion of the modeling capability across a broader global network

Requirements

  • Ph.D. or Master’s degree in chemical engineering, biochemical engineering, biotechnology, bioprocess engineering, life sciences, or a related field
  • Minimum of 5 years of experience in process development involving mammalian and/or microbial cell cultures
  • Deep understanding of process scaling principles and bioreactor engineering
  • Hands-on experience with process modeling, such as CFD modeling or related simulation tools
  • Strong knowledge of the mathematical principles behind scale-up and modeling
  • Proficiency in at least one programming or scripting language such as Python, R, or MATLAB
  • Ability to provide technical direction in complex development programs

Nice to have

  • Experience with Python, especially in relation to technical tool development or migration
  • Previous customer-facing experience
  • Experience in a CDMO or similarly complex multi-product environment
  • Prior leadership or team management experience

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