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Leveraging a proven track record of leading at least 3 discovery programs to clinic, The Global Therapeutic Research Lead (G-TRL) is a pipeline critical strategic leader responsible for driving Research projects to the clinic. The individual will sit on the Neuroscience Drug Discovery Unit (NS DDU) Leadership Team. Leader for at least one or more of Takeda's top priority oligonucleotide projects with substantial clinical and commercial potential with a clear accelerated path to the clinic. You will provide mentorship to team members to elevate enterprise thinking and capabilities of our drug discovery talent across the global Research function. As project lead, the G-TRL builds a connected view of the project within the Neuroscience TA strategy and treatment paradigm and can represent all core expertise at depth and align with stakeholders and sponsors across the organization including Research, Clinical Development and Commercial stakeholders and executive level governance committees. G-TRLs are responsible for creating the medicine vision, early asset strategy and managing multiple external partnerships that accelerate delivery of the project. G-TRLs will establish smart, fast, and critical path minded practices for groups, including integrating new strategies and competitive industry ways of working. G-TRL will advise on the continuous infusion of new Research projects aligned to strategy to generate a sustainable Research Engine generating a steady flow of high-quality INDs every year.
Job Responsibility
Lead and manage one or more 'Top 10' drug discovery oligonucleotide projects, overseeing the entire drug discovery process from target identification to preclinical development
Responsible for the articulation and ownership of the project strategy, developed in partnership with internal stakeholders
Contribute to strategy for future portfolio investment, particularly within the Inflammation and Immunology area including advising on which projects should be Top 10 projects
Evaluate and prioritize potential drug candidates based on scientific, medical, and commercial considerations
Represent all core expertise for project
Partner with Clinical and Translational teams to refine asset strategy
Ensure alignment to the therapeutic area strategy (i.e., Clinical Development)
Understand and align with commercial team for asset commercial value within the Neuroscience Therapeutic Area (NS TA)
Provide guidance and mentorship to global project team members, stimulating enterprise thinking and fostering their professional growth and development
Mentor future and more junior project leads and elevate drug discovery capability across Research
Collaborate with cross-functional teams and partners (e.g., DMPK, Pharmaceutical Sciences) within and outside Takeda to drive project delivery
Pipeline and enterprise impact through effective partnering with multiple internal and external collaborators
Provide strategic, process, and operational leadership for successful Top 10 Project delivery
Foster a culture of innovation and scientific excellence within the matrixed drug discovery team, promoting collaboration, knowledge sharing, and continuous learning
Become a world leading scientific expert in the projects you lead
Oversee the design and execution of experiments, data analysis, and interpretation to enable decision-making and optimize drug discovery efforts
Stay abreast of the latest advancements in drug discovery, emerging technologies, and industry trends, applying this knowledge to enhance drug discovery strategies
Build and maintain relationships with key stakeholders, including academic institutions, research organizations, and industry partners inclusive of serving on joint external governance committees across the globe
Represent Takeda externally for the Neuroscience Drug Discovery Unit and play a key role in evaluating external opportunities, serving as an effective ambassador for Takeda's global business development brand
Requirements
Advanced degree in health or life sciences (e.g., Ph.D., M.D., D.V.M.)
Expected to have at least 10-12 years industry and relevant subject matter expertise within Immunology and Inflammation and at least 10-12 years global management experience, including working effectively with matrix teams
Extensive experience in leading drug discovery teams and managing drug discovery/development projects, preferably in a pharmaceutical or biotechnology setting covering gastroenterology and inflammation
Deep understanding of the drug discovery process, including target identification, hit-to-lead optimization, and preclinical development, anticipating, and removing roadblocks
Proven track record of leading numerous projects, ideally 5+ projects, across discovery from target inception to Candidate Nomination or beyond
Played a major role in 3+ INDs
Has delivered clinical development assets preferably across multiple modalities (e.g. small molecule, biologics, cell therapies, ADC etc.)
Excellent and inclusive leadership with the ability to inspire and motivate diverse teams towards achieving ambitious goals
Reputation as a proactive, solutions-oriented leader who engages relevant expertise no matter where it resides
Strong business acumen and understanding of the pharmaceutical industry, including regulatory requirements and commercial considerations with relevant knowledge and expertise for specific modalities
Exceptional communication and presentation skills, with the ability to effectively communicate complex scientific concepts to diverse audiences
Proven ability to build and maintain collaborative relationships with internal and external stakeholders across a matrixed organization
Strong problem-solving and decision-making abilities, with a focus on data-driven decision making
Demonstrated success in building and managing strategic partnerships with academic institutions, research organizations, and industry collaborators
What we offer
Allowances: Commutation, Housing, Overtime Work etc.
Salary Increase: Annually, Bonus Payment: Twice a year
Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)
Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave
Flexible Work Styles: Flextime, Telework
Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc.