CrawlJobs Logo
Amgen Logo Amgen · Manufacturing

Front Line Manufacturing Manager - Upstream Bulk Drug Substance - Days

United States, Holly Springs Employment contract 106148.00 - 143612.00 USD / Year · Job Posted May 04, 2026
Apply Position
Job Link Share

Job Description

Let’s do this. Let’s change the world. Amgen is seeking a Manager Manufacturing Upstream to provide frontline leadership supporting the facility expansion program and facility startup. This essential role will lead a team responsible for manufacturing cell culture operations including seed train, SUBs, Perfusion, RTF, Stainless Steel BRXs, Depth Filtration and Centrifugation, while partnering across functions to ensure successful operational readiness, technology transfer, and ramp-up of manufacturing operations within the new facility.

Job Responsibility

  • Frontline Leadership: Lead, develop, and coach a manufacturing team
  • set clear performance expectations
  • foster a strong culture of safety, quality, and accountability
  • Facility Startup & Operational Readiness: Support design, build, commissioning, qualification (C&Q), staffing, training, and readiness milestones for a new manufacturing facility
  • Manufacturing Operations: Ensure safe, cGMP-compliant execution
  • drive performance across safety, quality, schedule, and cost
  • resolve deviations and operational issues
  • Technology Transfer & Process Implementation: Support transfer and implementation of manufacturing processes
  • ensure manufacturability, troubleshooting, and continuous improvement
  • Cross-Functional Collaboration: Partner with Quality, Engineering, NPI, Supply Chain, Validation, and Site Leadership to enable successful startup and ramp-up
  • Compliance & Inspection Readiness: Maintain inspection readiness and adherence to regulatory and Amgen quality standards
  • Continuous Improvement: Identify and drive efficiency, reliability, and scalability improvements as operations mature
  • Shift Support: Work non-standard hours as required, transitioning to a 12-hour 2-2-3 dayshift supporting 24/7 operations

Requirements

  • Doctorate degree OR Master's degree and 3 years of Manufacturing or Operations experience OR Bachelor's degree and 5 years of Manufacturing or Operations experience OR Associate's degree and 10 years of Manufacturing or Operations experience OR High school diploma / GED and 12 years of Manufacturing or Operations experience
  • AND Previous managerial experience directly managing people and/or experience leading teams, projects, programs or directing the allocation of resources

Nice to have

  • Bachelor's degree in Life Sciences or Engineering
  • Experience with facility startup, commissioning, or operational readiness
  • Biologics / drug substance manufacturing experience (Upstream)
  • cGMP manufacturing experience (5+ years preferred)
  • Experience with technology transfer and process implementation
  • Prior Area Lead / Specialist / Manager experience
  • Strong leadership, performance management, and conflict-resolution skills
  • Solid understanding of regulatory requirements
  • Proficiency with MES/EBR, DeltaV, Maximo, Veeva, LIMS, and electronic quality systems

What we offer

  • Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans and bi-annual company-wide shutdowns
  • Flexible work models, including remote work arrangements, where possible
Amgen - All Job Offers

Looking for more opportunities?

Search for other job offers that match your skills and interests.

Suggested Tags: Frontend Developer Secretary Talent Manager Salesforce Administrator Data Analyst
Similar Jobs for

Front Line Manufacturing Manager - Upstream Bulk Drug Substance - Days

8 matching positions

Resident Assistant

If you’re looking for a job that goes beyond the basics to deliver purpose and j...
Location
Location
United States of America , Hillsboro
Salary
Salary:
18.00 - 20.00 USD / Hour
leisurecare.com Logo
Leisure Care
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Demonstrated experience in a caregiving role
  • Current CNA a plus!
Job Responsibility
Job Responsibility
  • Assists resident with activities of daily living (ADL's) and all personal care skills (bathing, dressing, grooming, toileting)
  • Makes appropriate observations about the resident’s condition in every interaction
  • Records and follows-up with changes in resident’s condition in a timely manner
  • Assists residents with laundry and housekeeping services as needed
What we offer
What we offer
  • Medical, Dental and Vision
  • Early Wage Access (access to earned wages when needed!)
  • 401k
  • 10 days vacation & 1 hour Sick Leave earned for every 30 hours worked
  • Bereavement & Jury Duty Leave
  • 6 Holidays
  • 2 Float Holidays
  • Flexible Spending Accounts (Health and Dependent Care)
  • Meal Discounts
  • Tuition Assistance
  • Fulltime
Read More
Arrow Right

Traffic Management CAD Technician

FM Conway is currently recruiting a Traffic Management CAD Technician to join ou...
Location
Location
United Kingdom , Ipswich
Salary
Salary:
Not provided
jobs.360resourcing.co.uk Logo
360 Resourcing Solutions
Expiration Date
July 04, 2026
Flip Icon
Requirements
Requirements
  • Strong knowledge of Traffic Management operations
  • experience using CAD, BricsCAD and Cone 11 software
  • ability to read and translate blueprints and technical drawings
  • ability to work well under pressure, prioritise tasks effectively and have excellent attention to detail
  • M7 Lantra qualification is highly desirable, but not essential
Job Responsibility
Job Responsibility
  • Working within a team of Traffic Management development designers and Project Engineers to ensure that drawings are to a high and legal standard
  • Producing clear drawings, signage placement layouts and diversion route strategies
  • Developing safe and efficient traffic management plans for work sites and road network
  • Carrying out on site assessments as required
  • Designing sites in accordance with Chapter 8 TSM
  • Engaging with Project Teams & Engineers to respond effectively to working methods that require traffic Management designs that conform to a legal standard
What we offer
What we offer
  • Career and professional development
  • 23 days holiday plus bank holidays
  • Life assurance
  • Opportunities for internal and external training
  • Access to a wide range of shopping discounts through Rewarding Great People platform
  • Health and well-being benefits including 24-hour advice lines
  • Support from in-house mental health first aiders
  • Fulltime
Read More
Arrow Right

Registered Nurse, CVOR

Baptist Downtown is hiring a Registered Nurse for our Cardiovascular Operating R...
Location
Location
United States , Jacksonville
Salary
Salary:
Not provided
baptistjax.com Logo
Baptist Health (Florida)
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • 1-2 years Operating Room Nursing Experience Required
  • Basic Life Support (BLS) Required
  • Advanced Cardiac Life Support (ACLS) Required
  • Licensed Registered Nurse Required
  • Associate of Science, Nursing
  • Registered Nurse (RN) - State Nursing Boards
  • Driver's License - DMV
  • Basic Life Support (BLS) - AHA
  • Advanced Cardiac Life Support (ACLS) - AHA
Job Responsibility
Job Responsibility
  • Providing for patient needs as recognized through use of the nursing process
  • Supervision of care provided by supportive personnel and coordination of care provided by ancillary services
  • Including patients and significant others (SO)/families in developing an individualized plan of care
  • Education of patients/SO/families to their disease process and plan of care
  • Coordinating and preparing assigned operating room/case
  • Assessment of patient care needs and the anticipation of needs of the case
  • Circulating, scrubbing, assisting on Cardiothoracic and vascular procedures
  • Fulltime
Read More
Arrow Right

Pediatric Occupational Therapist

Wolfson Children's Hospital Rehab Services is hiring a Pediatric Occupational Th...
Location
Location
United States , Jacksonville
Salary
Salary:
Not provided
baptistjax.com Logo
Baptist Health (Florida)
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Bachelor's degree (or higher) in Occupational Therapy Required
  • Licensed Occupational Therapist from FL Department of Health Required
  • Basic Life Support (BLS) certification from the American Heart Association Required
  • Pediatric Occupational Therapy in the outpatient setting is strongly preferred
Job Responsibility
Job Responsibility
  • Evaluates and treats patients with developmental, neurological, orthopedic, and medical diagnoses
  • Extensive patient/family education
  • Works with multidisciplinary team care
What we offer
What we offer
  • $1,000 Sign on Bonus
Read More
Arrow Right

Nursery Manager

Join the Kindred Family – Lead, Inspire, and Make a Difference. Are you an exper...
Location
Location
United Kingdom , Hauxton
Salary
Salary:
34000.00 - 36000.00 GBP / Year
jobs.360resourcing.co.uk Logo
360 Resourcing Solutions
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Proven experience in leading and managing a team within early years
  • Strong written and verbal communication skills
  • Excellent organisational skills and attention to detail
  • Outstanding customer service and time management
  • Full and relevant Early Years Level 3 Childcare Qualification or higher
  • Sound knowledge of EYFS and OFSTED guidelines
Job Responsibility
Job Responsibility
  • Lead the Deputy Manager, Third in Charge, and Room Leaders to ensure high standards of Early Years care and education
  • Maintain an organised, safe, and stimulating nursery environment
  • Keep accurate records and ensure procedures are followed across the nursery
  • Build and maintain a reputation as the nursery of choice for children and staff
  • Model and monitor best practice in line with regulatory guidelines
  • Inspire and support your team, overseeing inductions, mentoring, and ongoing development
  • Ensure the nursery runs efficiently, meets KPIs, budgets, and targets, and is prepared for audits and inspections
  • Oversee the day-to-day operations of the nursery
  • Lead by example, modelling good practice and creating a shared vision
  • Supervise, support, and allocate tasks to your team
What we offer
What we offer
  • Birthday Off
  • 6 Fully Paid Sick Days
  • Cashback Healthcare Plan
  • Retail Discounts
  • Recognition & Reward Scheme
  • 50% Childcare Discount
  • 24/7 Virtual GP Access
  • 24/7 Counselling Support
  • Discounted Gym Membership
  • Personal Financial Advisor Access
  • Fulltime
Read More
Arrow Right

Waiter

We are looking for enthusiastic and service-oriented Waiters (Part-time 20 hours...
Location
Location
United Kingdom , London
Salary
Salary:
Not provided
jobs.360resourcing.co.uk Logo
360 Resourcing Solutions
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Previous experience in a restaurant, café, or hospitality environment is essential
  • Strong communication and interpersonal skills with a friendly, positive attitude
  • Ability to work in a fast-paced environment while maintaining excellent customer service
  • Attention to detail and a commitment to high standards
  • Well-presented with a professional appearance and good personal hygiene
  • Willingness to learn and adapt in a new and exciting restaurant setting
  • Availability to work flexible hours, including evenings, weekends, and holidays
Job Responsibility
Job Responsibility
  • Welcome and seat guests, ensuring a warm and professional dining experience
  • Provide detailed knowledge of the menu, ingredients, and specials to assist guests with their choices
  • Take accurate food and drink orders and communicate effectively with the kitchen and bar staff
  • Serve food and beverages efficiently, ensuring guests’ needs are met promptly
  • Maintain cleanliness and organization of tables and service areas
  • Ensure compliance with restaurant dress code and hygiene standards
  • Work collaboratively with colleagues to ensure smooth service and excellent customer satisfaction
  • Handle guest requests and feedback professionally and efficiently
  • Attend training sessions and team meetings as required
  • Perform additional duties as assigned by the Restaurant Manager
What we offer
What we offer
  • Competitive salary with service charge and staff benefits
  • Training and development opportunities to help you grow in the hospitality industry
  • A positive and supportive team environment with room for career progression
  • Parttime
Read More
Arrow Right

Sales Consultant

Want to be part of a high-energy team that works hard, has fun whilst doing it a...
Location
Location
United Kingdom , Northampton
Salary
Salary:
50000.00 - 60000.00 GBP / Year
jobs.360resourcing.co.uk Logo
360 Resourcing Solutions
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • You want to be here
  • want to do well
  • want to be heard
  • A team player with a strong work ethic
  • Happy to work weekends and deliver on our busiest sales days
  • Reliable, organised and confident in customer service and sales
  • Comfortable using systems and following processes with confidence in problem solving
  • Proud of your work and passionate about doing things right
Job Responsibility
Job Responsibility
  • Be the face of the store
  • Greet customers and build a rapport to understand their needs
  • Create an awesome end-to-end experience for all customers
  • Work towards individual and team sales targets
  • Communicating clearly and confidently with your team
  • Following health & safety procedures at all times
  • Making a difference every day to the customer experience
What we offer
What we offer
  • Competitive package: £25,500 plus £200 a week commission guarantee for first 13 weeks
  • OTE £50,000 - £60,000+
  • Work for an award-winning, family-run business
  • Annual Family Partnership celebration – recognising YOU!
  • Innovate & Grow: clear career path, full training and personal development opportunities
  • Staff discount
  • 24/7 medical support, health insurance and Perkbox benefits
  • 28 days holiday entitlement including bank holiday, increase to a maximum of 33 days based on length of service
  • Fulltime
Read More
Arrow Right

Care Assistant - Days

We are on the hunt in Harrogate for our next amazing Care Assistants! Our Care t...
Location
Location
United Kingdom , Harrogate
Salary
Salary:
13.27 GBP / Hour
jobs.360resourcing.co.uk Logo
360 Resourcing Solutions
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • No previous experience needed
  • no qualifications needed
  • must share and demonstrate our values: Humility, Accountability, Achievement, Passion, Integrity
  • Enhanced DBS check in relation to Children and Adults required
Job Responsibility
Job Responsibility
  • Support with personal care needs
  • help residents take part in special interests and activities such as arts and crafts, watching football, drama, musical evenings, gardening, shopping trips and social occasions
What we offer
What we offer
  • Flexible working patterns
  • Training and development opportunities tailored to you
  • Discounts on Shopping, Fashion, Days out, Travel, Entertainment and more
  • FREE face-to-face counselling for you and your family
  • Staff recognition award ceremonies
  • £30 voucher available every month for nominated 'Employee of the month'
  • Opportunities for training and career progression
  • Salary Sacrifice Pension scheme
  • Blue Light Card – up to 50% discount across 100’s of retailers
  • Access to a FREE eye test and discounted glasses
Read More
Arrow Right