DMPK Project Representative Job at Proclinical (Lexington)

Global Therapeutic Research Lead (Oligo)

Leveraging a proven track record of leading at least 3 discovery programs to cli...

Location

Japan , Kanagawa

Salary:

Not provided

BioLife Plasma Services

Expiration Date

Until further notice

Requirements

Advanced degree in health or life sciences (e.g., Ph.D., M.D., D.V.M.)
Expected to have at least 10-12 years industry and relevant subject matter expertise within Immunology and Inflammation and at least 10-12 years global management experience, including working effectively with matrix teams
Extensive experience in leading drug discovery teams and managing drug discovery/development projects, preferably in a pharmaceutical or biotechnology setting covering gastroenterology and inflammation
Deep understanding of the drug discovery process, including target identification, hit-to-lead optimization, and preclinical development, anticipating, and removing roadblocks
Proven track record of leading numerous projects, ideally 5+ projects, across discovery from target inception to Candidate Nomination or beyond
Played a major role in 3+ INDs
Has delivered clinical development assets preferably across multiple modalities (e.g. small molecule, biologics, cell therapies, ADC etc.)
Excellent and inclusive leadership with the ability to inspire and motivate diverse teams towards achieving ambitious goals
Reputation as a proactive, solutions-oriented leader who engages relevant expertise no matter where it resides
Strong business acumen and understanding of the pharmaceutical industry, including regulatory requirements and commercial considerations with relevant knowledge and expertise for specific modalities

Job Responsibility

Lead and manage one or more 'Top 10' drug discovery oligonucleotide projects, overseeing the entire drug discovery process from target identification to preclinical development
Responsible for the articulation and ownership of the project strategy, developed in partnership with internal stakeholders
Contribute to strategy for future portfolio investment, particularly within the Inflammation and Immunology area including advising on which projects should be Top 10 projects
Evaluate and prioritize potential drug candidates based on scientific, medical, and commercial considerations
Represent all core expertise for project
Partner with Clinical and Translational teams to refine asset strategy
Ensure alignment to the therapeutic area strategy (i.e., Clinical Development)
Understand and align with commercial team for asset commercial value within the Neuroscience Therapeutic Area (NS TA)
Provide guidance and mentorship to global project team members, stimulating enterprise thinking and fostering their professional growth and development
Mentor future and more junior project leads and elevate drug discovery capability across Research

What we offer

Allowances: Commutation, Housing, Overtime Work etc.
Salary Increase: Annually, Bonus Payment: Twice a year
Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)
Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave
Flexible Work Styles: Flextime, Telework
Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc.

Fulltime

Principal Scientist PKPD

CK Group are recruiting for a Principal Scientist PKPD to join a global pharmace...

Location

United Kingdom , Slough

Salary:

35.20 - 47.92 GBP / Hour

CK Group

Expiration Date

Until further notice

Requirements

Experience working in a matrix environment, to help design and set non-clinical PKPD study protocols, and analyze, interpret, and report PKPD results including GLP toxicokinetics studies
PhD/MSc/BSc relevant discipline (quantitative pharmacology
pharmacokinetics /pharmacodynamics
DMPK, etc.) with more than 5 years hands on experience in PKPD data analysis within a pharma company or CRO environment
Good understanding of pharmacology and pharmacologic processes related to disease and drug mechanisms
Hands-on experience in delivering high quality pre-clinical PKPD data analysis
Proficiency in the use of Phoenix- WinNonlin for PKPD analysis is essential
Good written and verbal communication skills, and ability to communicate study results and produce high standard reports that meet regulatory submission standards
It is essential that applicants hold entitlement to work in the UK

Job Responsibility

Participate in the development of non-clinical PKPD and GLP toxicokinetics studies
Lead the non-clinical PKPD strategy
Participate in protocol designs and writing by providing scientific support and input into regulatory study designs and protocols
Work collaboratively with the project teams representatives (e.g. Non-Clinical Safety, Bioanalysis, Clinical Pharmacology) and with the CROs, to ensure high quality data is generated
Deliver PKPD study reports and integrated summaries of the studies and participate in regulatory submission documents
Facilitate the advancement of drug candidates by building a thorough knowledge of the drug pharmacology and PKPD

Fulltime

Head of Drug Metabolism and Pharmacokinetics

IRBM is seeking an accomplished and highly motivated Head of Drug Metabolism and...

Location

Italy , Pomezia

Salary:

Not provided

IRBM

Expiration Date

Until further notice

Requirements

PhD (or equivalent) in Pharmaceutical Sciences, Pharmacology, Biochemistry, Chemistry, Molecular Biology, or related discipline
8+ years of industry experience in drug discovery and development
Expertise in pharmacokinetics, drug metabolism, and ADME for small molecules and biologics
Knowledge of PK/PD modeling to support candidate selection and human exposure predictions
Experience leading multidisciplinary teams in a fast-paced, collaborative environment
Strong communication skills and proven ability to influence scientific and development decisions

Job Responsibility

Provide scientific, strategic, and operational leadership for all DMPK activities across CRO activities and internal programs
Define and implement DMPK strategy to support candidate selection, lead optimization, and preclinical development
Lead and mentor the DMPK team in the design, execution, analysis, and reporting of PK/ADME and bioanalytical studies
Oversee both CRO studies and internal discovery programs, ensuring high-quality data, timely delivery, and partner satisfaction
Serve as a senior scientific interface with external partners and internal teams, advising on study design, data interpretation, and problem-solving
Represent DMPK on cross-functional project teams and integrate activities across R&D to align with portfolio goals
Implement best practices, emerging technologies, and workflows to drive innovation and operational excellence
Support business development and portfolio decisions by contributing DMPK expertise to proposals, project planning, and strategic discussions

Fulltime

Scientist / Senior Scientist, DMPK

An exciting opportunity is available for an enthusiastic and highly-skilled Scie...

Location

United States , San Francisco Bay Area; San Diego

Salary:

132500.00 - 247200.00 USD / Year

Altos Labs

Expiration Date

Until further notice

Requirements

PhD in Chemistry, Biology, Pharmaceutical Sciences, or a related field and 3+ years of relevant work experience
Strong fundamental knowledge of DMPK and ADME
Working knowledge of ADME assays and bioanalysis, leveraged to design studies and interpret data
Ability to evaluate in vitro-in vivo correlation of drug candidates across preclinical species
Ability to generate NCA and compartmental PK models
general knowledge of mechanistic modeling concepts (e.g., PBPK)
Ability to communicate DMPK results in a timely, clear, and impactful manner to non-DMPK scientists
Exceptional organizational skills, attention to detail, time management, and ability to work independently and collaboratively
Willingness to gain new knowledge and apply it to support multiple therapeutic modalities

Job Responsibility

Serve as the DMPK representative on cross-disciplinary preclinical project teams, providing strategic and data-driven DMPK guidance to advance portfolio programs
Plan, manage, and oversee ADME and PK studies executed with external CRO partners
Partner with Medicinal Chemistry to develop ADME- and PK-driven SAR strategies to optimize candidate properties and progression
Collaborate with Pharmacology and the internal DMPK bioanalysis group to design, execute, and interpret preclinical PK/PD, target engagement, and efficacy studies
Calculate the projected efficacious human dose to support IND-enabling development and regulatory submissions
Provide DMPK support to early-stage, pre-portfolio discovery programs, helping shape strategy and experimental plans
Advise and train the DMPK bioanalysis team to support internalization and implementation of select ADME assays
Stay current on emerging DMPK science and best practices through literature review and participation in relevant scientific meetings

Fulltime

New

Construction Rigger

If you’re looking for a career with a company that has a ‘Can Do’ attitude, then...

Location

Australia , Kalgoorlie

Salary:

Not provided

Primero Group

Expiration Date

Until further notice

Requirements

Have strong industrial construction working experience, at least 5 years
Strong steel erection and mechanical experience on large scale mining construction projects
Tilt panel experience
Flexible work ethic and able to adapt to changing work environments, including nightshift if required
Good communication skills and accuracy in record keeping
Excellent safety awareness and values
High Risk Work Licence (RA, RI, WP)
Drivers Licence C-Class
Confined space Entry
Working at Heights

What we offer

Competitive Compensation
Contemporary Rostering
Career Opportunities
Paid Parental Leave
Health and Wellbeing Support
Benefits & Discounts
Employee Referral Rewards

Fulltime

New

Staff Pharmacist

We’re building a world of health around every individual — shaping a more connec...

Location

United States , Streetsboro

Salary:

60.00 - 76.00 USD / Hour

CVS Health

Expiration Date

August 25, 2026

Requirements

Active Pharmacist License in the state where the Store is located
Active National Provider Identifier (NPI)
Not on the DEA Excluded Parties list

Job Responsibility

Living our purpose by helping to manage and improve patient health through safe and appropriate dispensing, counseling, and immunizing practices
Taking direction from the Pharmacy Manager and overseeing the pharmacy as their proxy during bench shifts without overlap, including strengthening pharmacy performance measures through effective coaching and consistent follow-up of pharmacy team members and providing feedback about pharmacy team performance to the Pharmacy Manager as needed
Assumes Pharmacy Manager's day-to-day duties when serving as the only or the primary pharmacist-on-duty
Supporting safe and accurate prescription fulfillment by following—and directing the pharmacy team to follow—pharmacy workflow procedures and utilizing the safety guardrails at every workstation
Contributing to positive patient experiences by showing empathy and genuine care, and coaching the pharmacy team to do the same: demonstrating compassionate care, collaborating with the patient's total healthcare team, and proactively resolving insurance and/or medication issues
Proactively offering and delivering immunizations to keep patients healthy
engaging and supporting Pharmacy Technicians to learn to immunize
Supporting the effective management of pharmacy inventory by following—and coaching the pharmacy team to follow—all inventory best practices, with a special focus on protecting cold chain products for our patients and our business
Partnering with the Pharmacy Manager to ensure pharmacy operations are compliant with the appropriate state Board of Pharmacy regulations at all times
escalating issues or concerns to the Pharmacy Manager and/or Rx DL for timely resolution if/as needed

What we offer

Medical, dental, and vision coverage
Paid time off
Retirement savings options
Wellness programs
Bonus, commission or short-term incentive program

Fulltime

New

Banquet Cooks

Toasted Oak Grill & Market located inside the Renaissance Baronette Hotel is see...

Location

United States , Novi

Salary:

19.00 - 21.00 USD / Hour

Marriott Bonvoy

Expiration Date

Until further notice

Requirements

High school diploma or equivalent preferred
Prior banquet food preparation
Ability to follow recipes and maintain consistency in food quality
Strong attention to detail and organizational skills
Commitment to safety and sanitation standards
Positive attitude and ability to work effectively in a team environment

Job Responsibility

Flexibility with the ability to work days, nights and weekends when needed
Oversee the process and team while preparing banquet food and prep throughout the week
Prepare banquet orders with adherence to guest requests and special needs in a positive manner
Work other stations when needed
Prepare food of consistent quality
Properly document all food containers with adherence to rotations
Practice safety standards at all times
Report to work in full clean uniform, on time, and ready to serve

What we offer

Competitive wages / $20 hour
Medical, dental, and vision insurance packages
Life insurance and short/long-term disability options - company paid short term
401(k) with company match
Paid holidays, paid time off, tuition reimbursement and so much more

Fulltime

New

Senior Engineer - Throughput Simulations

Sponsorship:  GM DOES NOT PROVIDE IMMIGRATION-RELATED SPONSORSHIP FOR THIS ROLE....

Location

India , Bengaluru

Salary:

Not provided

General Motors

Expiration Date

Until further notice

Requirements

Master's or Bachelor's degree in Mechanical / Production/ Automobile Engineering discipline
3-10 Years of Experience in Throughput Simulation/Material Flow Simulation for Automotive Plant
Hands-on experience with Siemens Plant Simulation, AutoCAD
Hands-on experience with SimTalk 2 to code logics of simulation model
Knowledge about workflow and processes in Body, Paint, General Assembly and propulsion systems
Knowledge about throughput behaviors and production systems
Knowledge in Python and other scripting languages
Knowledge of Lean Manufacturing Strategy (ex. TOC)
Ability to address unusual and/or difficult problems with analytical ability and problem-solving techniques
Understanding of lean manufacturing principles, layout design and Material flow and layouts

Job Responsibility

Build, maintain, and improve Plant Simulation models that represent production and material flow behavior for manufacturing systems
Analyze throughput, identify bottlenecks, evaluate capacity constraints, and recommend actions to help the system achieve required output
Study machine utilization, processing behavior, setup time, failure impacts, and buffer performance to improve line flow and system stability
Configure and use material flow, resources, and mobile objects within Plant Simulation to run scenario-based what-if studies
Translate production plans and operating assumptions into simulation-ready inputs and model logic
Prepare clear results summaries, charts, and recommendations for engineering and project stakeholders

Fulltime

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DMPK Project Representative

Job Description

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