CrawlJobs Logo
GSK Logo GSK · IT - Software Development

Dmpk Modeller

Spain, Madrid Employment contract 60525.00 - 100875.00 EUR / Year · Job Posted June 10, 2026
Apply Position
Job Link Share

Job Description

You will join a DMPK drug discovery team in Spain to influence how we translate science into safer, more effective medicines. You will design and deliver modelling and simulation strategies to support discovery and early development projects. You will work closely with project teams across disciplines and locations to inform dose decisions, drug-drug interaction risk, and human pharmacokinetics. We value collaborative thinkers who communicate clearly, mentor others, and apply modelling with scientific rigour and practical judgement. This role is part of GSK's Global Health Medicines R&D team which aims to positively impact infectious diseases such as Malaria, Tuberculosis, and AMR that disproportionally impact lower income countries.

Job Responsibility

  • Lead development and application of pharmacokinetic and pharmacokinetic-pharmacodynamic (PK/PD) models for small molecules and other modalities to inform project decisions
  • Design and deliver translational modelling strategies, including dose prediction and human exposure projections
  • Assess and quantify drug-drug interaction (DDI) risk using in vitro-in vivo translation and modelling approaches
  • Communicate model assumptions, results and uncertainty clearly to cross-functional teams and governance bodies
  • Mentor and coach colleagues on modelling methods, good practices and scientific interpretation
  • Contribute to regulatory and internal documents with clear, evidence-based modelling narratives

Requirements

  • Degree in Pharmacology, Pharmaceutics, Pharmacokinetics, Mathematics, Bioengineering, or a related discipline
  • Practical experience in population PK, PBPK, or mechanistic PK/PD modelling in a biopharma setting
  • Hands-on experience with modelling software such as, Matlab (symbiology), Monolix, Simcyp, GastroPlus, or equivalent
  • Experience translating in vitro and preclinical data to humans
  • Strong written and verbal communication skills in English
  • ability to explain modelling outcomes to non-specialists
  • Experience working in cross-functional project teams

Nice to have

  • PhD in a relevant field or equivalent industry experience
  • Experience with drug-drug interaction modelling and enzyme/transporter mechanistic frameworks
  • Familiarity with multiple modalities beyond small molecules
  • Experience preparing modelling sections for regulatory documents and interacting with regulators
  • Programming skills in R, MATLAB, or Python for data analysis and model development
  • Experience in infectious disease drug discovery
  • Track record of mentoring and developing junior scientists

What we offer

  • Competitive base salary
  • Annual bonus based on company performance
  • Flexible working options available for most roles
  • Learning and career development
  • Access to healthcare & wellbeing programmes
  • Employee recognition programmes
GSK - All Job Offers

Looking for more opportunities?

Search for other job offers that match your skills and interests.

Suggested Tags: Frontend Developer Secretary Talent Manager Salesforce Administrator Data Analyst
Similar Jobs for

Dmpk Modeller

8 matching positions

Director, Clinical Pharmacology

As a Director of Clinical Pharmacology, you will be responsible for planning, ma...
Location
Location
Denmark
Salary
Salary:
Not provided
life-science-talent-solutions.dk Logo
Life Science Talent
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • PhD or equivalent in Clinical Pharmacology, Pharmacometrics, or a related field
  • Minimum of 6 years of experience in clinical pharmacology and pharmacometrics within the pharmaceutical or biotechnology industry
  • Prior experience managing/leading program level clinical pharmacology deliverables at a Biopharma or Biotech is highly preferred. Alternatively, experience working at CROs leading clinical pharmacology and/or pharmacometrics workflows for biologics development is also considered
  • Demonstrated expertise in analyzing/interpreting clinical pharmacology endpoints (PK, PD data) and using them for designing PK-PD modeling and pharmacometrics modules to achieve clinical PoC
  • Strong background in pharmacokinetic and pharmacodynamic principles, with hands-on experience in study design, data analysis, and interpretation
  • Prior working experience closely with clinical development, biostats and regulatory teams towards regulatory filings is highly preferred
  • Prior experience managing clinical pharmacology CROs/consultants is preferred
  • DMPK (Drug Metabolism and Pharmacokinetics) expertise and bioanalytical experience are preferred and would be valuable additions to the role
  • Experience with immunogenicity assessments for biologics is preferred
  • Awareness of Nonclinical PK and toxicokinetic (TK) assessment for regulatory filings is preferred but not a must
Job Responsibility
Job Responsibility
  • Primarily spearhead and execute the clinical pharmacology strategy beginning in pre-phase 1/2 and through pivotal studies and approvals
  • Contribute as clinical pharmacology lead for establishing clinical proof-of-concept (PoC), dosing recommendations, clinical study design/execution documents and regulatory filings by working cross-functionally primarily with clinical development, clinical operations, regulatory and quality teams
  • Lead PK-PD modeling and pharmacometrics workflows and manage related vendors/consultants for timely deliverables
  • Design and oversee pharmacokinetic and pharmacodynamic studies to support dose selection, safety assessments, and efficacy evaluations
  • Evaluate, select and manage CROs/consultants that meet the specific program's needs and timelines
  • Maintain excellent relationships built on transparent and effective communications with external stakeholders
  • Keep abreast with current regulatory and industry practices in clinical pharmacology for biologics development
  • Provide clinical pharmacology expertise for regulatory interactions and submissions, including IND, NDA/BLA filings
  • Be a dedicated team player and flexible with constructive feedback from other functional leads unique to each program goals and challenges
  • Excellent program management skills combined with a strong scientific mindset
  • Fulltime
Read More
Arrow Right

Head of Drug Metabolism and Pharmacokinetics

IRBM is seeking an accomplished and highly motivated Head of Drug Metabolism and...
Location
Location
Italy , Pomezia
Salary
Salary:
Not provided
irbm.com Logo
IRBM
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • PhD (or equivalent) in Pharmaceutical Sciences, Pharmacology, Biochemistry, Chemistry, Molecular Biology, or related discipline
  • 8+ years of industry experience in drug discovery and development
  • Expertise in pharmacokinetics, drug metabolism, and ADME for small molecules and biologics
  • Knowledge of PK/PD modeling to support candidate selection and human exposure predictions
  • Experience leading multidisciplinary teams in a fast-paced, collaborative environment
  • Strong communication skills and proven ability to influence scientific and development decisions
Job Responsibility
Job Responsibility
  • Provide scientific, strategic, and operational leadership for all DMPK activities across CRO activities and internal programs
  • Define and implement DMPK strategy to support candidate selection, lead optimization, and preclinical development
  • Lead and mentor the DMPK team in the design, execution, analysis, and reporting of PK/ADME and bioanalytical studies
  • Oversee both CRO studies and internal discovery programs, ensuring high-quality data, timely delivery, and partner satisfaction
  • Serve as a senior scientific interface with external partners and internal teams, advising on study design, data interpretation, and problem-solving
  • Represent DMPK on cross-functional project teams and integrate activities across R&D to align with portfolio goals
  • Implement best practices, emerging technologies, and workflows to drive innovation and operational excellence
  • Support business development and portfolio decisions by contributing DMPK expertise to proposals, project planning, and strategic discussions
  • Fulltime
Read More
Arrow Right

Senior Scientist, Translational Biology

Join our Translational Biology team to help turn biological insight into tomorro...
Location
Location
Denmark , København
Salary
Salary:
Not provided
life-science-talent-solutions.dk Logo
Life Science Talent
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • A Ph.D. in biology, biomedicine, or a related field
  • +5 years of industry experience in Pharma or Biotech
  • Strong track record in drug discovery and early development
  • Proven expertise in cell-based assay development, optimization, and troubleshooting across multiple assay modalities (e.g. functional assays, ligand-based assays, flow cytometry) and a keen interest in lab-based work
  • Scientific background in immunology, chronic inflammatory diseases, and/or cardiometabolic diseases
  • Demonstrated ability to balance hands-on experimental work with scientific leadership and external oversight
Job Responsibility
Job Responsibility
  • Design, establish, and optimize disease-relevant cell-based assays to characterize function and potency of drug candidates
  • Perform and interpret critical experiments, particularly during assay setup, troubleshooting, and at key decision points
  • Ensure data quality, robustness, and biological relevance of in vitro datasets
  • Lead in vitro pharmacology efforts within discovery projects and define assay strategies that support translational understanding and go/no-go decisions
  • Contribute deep understanding of disease biology and cellular mechanisms to guide target selection and project strategy
  • Communicate complex scientific data clearly to multidisciplinary stakeholders
  • Identify, evaluate, and recommend relevant expert CRO’s and collaboration partners for assay and model development
  • Oversee CRO-generated data packages, providing scientific direction, critical review, and integration into internal project decisions
  • Identify and implement new assay technologies, platforms, and experimental approaches that strengthen translational confidence
  • Collaborate closely with Screening Biology, DMPK and project teams to ensure alignment across discovery stages
  • Fulltime
Read More
Arrow Right

Scientist / Senior Scientist, DMPK

An exciting opportunity is available for an enthusiastic and highly-skilled Scie...
Location
Location
United States , San Francisco Bay Area; San Diego
Salary
Salary:
132500.00 - 247200.00 USD / Year
altoslabs.com Logo
Altos Labs
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • PhD in Chemistry, Biology, Pharmaceutical Sciences, or a related field and 3+ years of relevant work experience
  • Strong fundamental knowledge of DMPK and ADME
  • Working knowledge of ADME assays and bioanalysis, leveraged to design studies and interpret data
  • Ability to evaluate in vitro-in vivo correlation of drug candidates across preclinical species
  • Ability to generate NCA and compartmental PK models
  • general knowledge of mechanistic modeling concepts (e.g., PBPK)
  • Ability to communicate DMPK results in a timely, clear, and impactful manner to non-DMPK scientists
  • Exceptional organizational skills, attention to detail, time management, and ability to work independently and collaboratively
  • Willingness to gain new knowledge and apply it to support multiple therapeutic modalities
Job Responsibility
Job Responsibility
  • Serve as the DMPK representative on cross-disciplinary preclinical project teams, providing strategic and data-driven DMPK guidance to advance portfolio programs
  • Plan, manage, and oversee ADME and PK studies executed with external CRO partners
  • Partner with Medicinal Chemistry to develop ADME- and PK-driven SAR strategies to optimize candidate properties and progression
  • Collaborate with Pharmacology and the internal DMPK bioanalysis group to design, execute, and interpret preclinical PK/PD, target engagement, and efficacy studies
  • Calculate the projected efficacious human dose to support IND-enabling development and regulatory submissions
  • Provide DMPK support to early-stage, pre-portfolio discovery programs, helping shape strategy and experimental plans
  • Advise and train the DMPK bioanalysis team to support internalization and implementation of select ADME assays
  • Stay current on emerging DMPK science and best practices through literature review and participation in relevant scientific meetings
  • Fulltime
Read More
Arrow Right

DMPK Project Representative

Project Representative - Contract - Lexington MA. Ready to represent projects th...
Location
Location
United States , Lexington
Salary
Salary:
120.00 - 140.00 USD / Hour
proclinical.com Logo
Proclinical
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Strong expertise in ADME principles
  • Knowledge of PK-PD modeling or biotransformation highly desirable
  • Proven ability to troubleshoot complex scientific challenges independently and collaboratively
  • Experience working with CROs and managing outsourced ADME-related projects
  • Excellent communication skills to convey scientific findings to diverse audiences
  • Relevant publications or abstracts in metabolism, drug interaction, or PK-PD modeling
  • Proficiency in cross-cultural collaboration and teamwork
  • Bachelor's degree in a relevant field required
  • Advanced degrees (Master's or Doctorate) with industry or post-doctoral experience preferred
Job Responsibility
Job Responsibility
  • Serve as the DMPK project representative for global cross-functional teams to achieve project objectives
  • Provide expert guidance on experimental plans and data interpretation, particularly in ADME-PK-DDI or PK-PD modeling and simulation
  • Design, implement, and interpret DMPK experiments in collaboration with Contract Research Organizations (CROs)
  • Analyze complex datasets, connect findings, and present conclusions to stakeholders
  • Document all experimental activities and results accurately
  • Actively participate in cross-functional meetings to drive project success and share knowledge
  • Write and review research manuscripts, project documents, and milestone reports
  • Represent the organization at scientific conferences and global meetings as a subject matter expert
Read More
Arrow Right
New

Implementation & Configuration Specialist

As an Implementation & Configuration Specialist (ICS), you will be responsible f...
Location
Location
India , Bengaluru
Salary
Salary:
Not provided
radancy.com Logo
Radancy
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • 2-4 years’ experience in technical configuration, implementation, or related digital delivery roles
  • Bachelor’s Degree preferred
  • Demonstrated experience with CMS platforms, web technologies, and digital integrations
  • Strong analytical and problem-solving skills
  • Detail-oriented with a focus on quality and repeatable results
  • Experience working in cross-functional teams
  • Excellent verbal and written communication skills
  • Ability to manage multiple configuration tasks across concurrent projects
Job Responsibility
Job Responsibility
  • Owns platform admin setup and configuration for new and existing projects
  • Manages customer domain and SSL setup processes
  • Executes translation, asset, and copy updates within CMS and related platforms
  • Builds and configures CMS pages, including URL redirects and SS page migrations
  • Maps jobs and scripts to ensure accurate data flow and reporting
  • Configures recruiter tools (CRM, Referrals, Events) as required by project scope
  • Develops and executes test plans and launch day checklists for configuration tasks
  • Collaborates with creative, UI, QA, and product teams to ensure seamless configuration and integration
  • Troubleshoots and resolves configuration issues throughout the project lifecycle
  • Documents configuration processes and updates project documentation as needed
  • Fulltime
Read More
Arrow Right
New

Dispatcher

We are looking for a reliable and attentive Dispatcher to join our team in Henri...
Location
Location
United States , Henrico
Salary
Salary:
Not provided
https://www.roberthalf.com Logo
Robert Half
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • Previous dispatch, logistics, transportation, or operations coordination experience strongly preferred
  • Strong geographic awareness and ability to understand freight routes and regional logistics
  • Ability to manage multiple priorities and make quick decisions in a fast-paced environment
  • Excellent communication skills, both over the phone and in person
  • Proficiency in Microsoft Office, particularly Excel
  • Strong problem-solving skills and ability to adapt to changing operational needs
  • Highly organized with strong attention to detail
  • Positive attitude with a strong work ethic and eagerness to learn
  • Ability to collaborate effectively with multiple teams and department
Job Responsibility
Job Responsibility
  • Coordinate nightly freight movement, ensuring loads are efficiently planned and routed
  • Manage high call volumes with terminals and internal dispatch teams to coordinate shipments
  • Plan and assign loads to appropriate drivers, routes, and equipment to ensure timely delivery
  • Communicate with terminals across multiple hubs to organize freight movement and resolve routing challenges
  • Collaborate with other dispatchers to coordinate shipments moving across different territories or regions
  • Monitor freight flow and adjust plans in real time based on shipment volume, operational needs, or delays
  • Utilize internal systems and Microsoft Excel to track loads, routes, and operational updates
  • Identify and resolve logistical issues quickly to keep freight moving efficiently
What we offer
What we offer
  • medical
  • vision
  • dental
  • life and disability insurance
  • 401(k) plan
  • Fulltime
Read More
Arrow Right
New

Dispatcher

The Dispatcher plays a critical role in coordinating efficient and safe transpor...
Location
Location
United States , Broderick
Salary
Salary:
Not provided
https://www.roberthalf.com Logo
Robert Half
Expiration Date
Until further notice
Flip Icon
Requirements
Requirements
  • High school diploma or equivalent required
  • associate's or bachelor's degree preferred
  • Minimum 2–3 years of experience in dispatching, logistics coordination, customer service, or transportation operations (experience in trucking, courier, rideshare, or emergency services is a plus)
  • Strong geographic knowledge of the operating area and familiarity with mapping/routing software (e.g., Samsara, Motive, Route4Me, Google Maps)
  • Proficient with transportation management systems (TMS), GPS tracking platforms, and Microsoft Office/Google Workspace
  • Excellent verbal and written communication skills
  • ability to remain calm and professional in high-stress situations
  • Superior multitasking and problem-solving abilities
  • Flexible schedule with ability to work evenings, weekends, holidays, and on-call shifts as required
  • Bilingual skills (English/Spanish or other relevant languages) a strong plus
Job Responsibility
Job Responsibility
  • Receive, prioritize, and assign service requests, delivery orders, or transportation jobs to drivers in real-time
  • Monitor driver locations, vehicle status, and route progress using GPS and fleet-management software
  • Communicate clearly and frequently with drivers via phone, radio, and messaging apps regarding route changes, traffic conditions, delays, or customer requirements
  • Proactively resolve issues such as vehicle breakdowns, traffic delays, customer complaints, or schedule conflicts
  • Optimize routes and loads to improve efficiency, reduce costs, and meet delivery windows
  • Maintain accurate records of driver logs, delivery statuses, proof of delivery, and incident reports
  • Coordinate with customers to confirm appointments, provide ETA updates, and handle special instructions
  • Ensure compliance with DOT regulations, hours-of-service rules, safety protocols, and company policies
  • Assist with emergency response and after-hours/on-call coverage as needed
  • Prepare daily, weekly, and monthly reports on performance metrics (on-time percentage, miles driven, etc.)
What we offer
What we offer
  • Medical, vision, dental, and life and disability insurance
  • 401(k) plan
  • Free online training
Read More
Arrow Right