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Amgen Logo Amgen · Research and Development

Director - Targeted Protein Degradation

United States, Thousand Oaks 206541.50 - 279438.50 USD / Year · Job Posted June 14, 2026
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Job Description

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Job Responsibility

  • Build upon Amgen's differentiated Induced Proximity Platform to define and execute a long-term scientific vision for targeted protein degradation and proximity-based therapeutics
  • Establish a differentiated scientific strategy that identifies where degradation and proximity-based mechanisms can uniquely address high-value biological targets
  • Drive innovation across the targeted protein degradation landscape, including molecular glues, heterobifunctional degraders, tissue-selective degraders, event-driven pharmacology, and emerging induced proximity modalities
  • Develop frameworks for identifying, evaluating, and prioritizing new biological opportunities enabled by targeted protein degradation and proximity biology
  • Anticipate emerging scientific, technological, and competitive trends and translate them into actionable platform strategies and capability investments
  • Serve as a key scientific advisor to Research leadership
  • Foster a culture of scientific ambition, rigor, and innovation
  • Define and build next-generation capabilities required to enable world-leading targeted protein degradation discovery
  • Champion the integration of AI- and data-driven approaches
  • Drive the development and adoption of novel experimental and computational technologies
  • Establish scalable scientific workflows and decision-making frameworks
  • Identify capability gaps and proactively build internal expertise, external partnerships, and enabling technologies
  • Build, mentor, and develop a high-performing multidisciplinary team
  • Foster a culture of collaboration, accountability, inclusion, and scientific excellence
  • Attract, develop, and retain exceptional scientific talent
  • Enable a highly innovative environment
  • Partner closely with Therapeutic Areas, Medicinal Chemistry, Research Informatics, Translational Sciences, Pharmacology, and Development organizations
  • Drive alignment across functions
  • Identify and evaluate emerging scientific advances, enabling technologies, and partnership opportunities
  • Cultivate a broad external network of scientific leaders and innovators
  • Represent the IPP organization in scientific, strategic, and executive forums

Requirements

  • Doctorate degree and 4 years of scientific experience
  • Master's degree and 8 years of scientific experience
  • Bachelor's degree and 10 years of scientific experience
  • at least 4 years experience directly managing people and/or leadership experience leading teams, projects, programs, or directing the allocation or resources

Nice to have

  • PhD in Chemical Biology, Biochemistry, Molecular Biology, Pharmacology, Medicinal Chemistry, or a related scientific discipline
  • Recognized scientific leader with significant contributions to targeted protein degradation, molecular glues, induced proximity biology, or adjacent fields
  • Deep understanding of degrader mechanisms, E3 ligase biology, chemical proteomics, structural biology, and translational pharmacology
  • Experience establishing scientific strategies, building research capabilities, and driving organizational transformation
  • Strong understanding of emerging computational and AI-enabled approaches in drug discovery
  • Demonstrated success developing strategic external collaborations and evaluating innovative technologies
  • Exceptional communication, influencing, and leadership skills with the ability to engage audiences ranging from scientific teams to executive leadership

What we offer

  • Comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions
  • group medical, dental and vision coverage
  • life and disability insurance
  • flexible spending accounts
  • discretionary annual bonus program
  • stock-based long-term incentives
  • award-winning time-off plans
  • flexible work models
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